AI Article Synopsis
- Chagas disease is caused by the parasite Trypanosoma cruzi, which can lead to severe heart issues in some infected individuals, particularly during the chronic phase.
- Most people infected with Chagas disease show no symptoms, but some may develop chronic chagasic cardiomyopathy, a serious form affecting the heart.
- Research has found that certain genotypes (PIK3CG CT and TT) are linked to a higher risk of developing this cardiac form, indicating that the T allele could play a role in distinguishing between types of Chagas disease manifestations.
Article Abstract
Chagas disease is caused by the protozoan parasite Trypanosoma cruzi. During the chronic phase of disease, while most infected people do not present symptoms, characterizing the asymptomatic form, some patients develop the cardiac form or chronic chagasic cardiomyopathy, which is considered the most severe manifestation of this disease. Considering that the activation of the PI3Kγ signaling pathway is essential for an efficient immune response against T. cruzi infection, we evaluated the PIK3CG C > T (rs1129293) polymorphism in exon 3 of this gene, which encodes the catalytic subunit of PI3Kγ. The PIK3CG CT and TT genotypes were found to be associated with an increased risk of developing the cardiac form of the disease rather than the asymptomatic or digestive forms. In conclusion, the presence of the T allele at single or double doses may differentiate the cardiac from other clinical manifestations of Chagas disease. This finding should help in further studies to evaluate the mechanisms underlying the differential association of PIK3CG in Chagas disease.
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| http://dx.doi.org/10.1016/j.meegid.2020.104671 | DOI Listing |
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