AI Article Synopsis
- Gastric emptying is crucial for understanding blood sugar responses in type 2 diabetes (T2DM), and the study investigated how chronic blood sugar control impacts this process.
- The research involved T2DM patients with different glycaemic control levels consuming a glucose drink, and their gastric emptying times were compared with those of young and older non-diabetic controls.
- Findings revealed that older adults had slower gastric emptying, while well-controlled T2DM patients emptied faster than older controls, suggesting potential ways to manage post-meal blood sugar levels in T2DM patients.
Article Abstract
Aim: Gastric emptying is a major determinant of the glycaemic response to carbohydrate and is frequently abnormal in type 2 diabetes (T2DM). There is little information about how chronic glycaemic control affects gastric emptying in T2DM. We evaluated gastric emptying of a 75 g glucose drink in community-based patients with T2DM of short duration with good or poor glycaemic control, and compared this to young and older controls.
Methods: T2DM patients managed by diet and/or metformin, either well-controlled or poorly-controlled, together with young and age-matched older controls without diabetes, consumed a 75 g oral glucose drink containing 150 mg C-acetate for evaluation of gastric emptying (breath test) and blood glucose over 180 min.
Results: The gastric half-emptying time (T50) was longer in the older than the young non-diabetic subjects (P = 0.041), but shorter in well-controlled T2DM patients than age-matched older controls (P = 0.043). The T50 in poorly-controlled T2DM patients was shorter than in older controls (P = 0.006), but similar to young non-diabetic subjects.
Conclusions: Gastric emptying of a glucose drink is delayed with ageing, but more rapid in patients with T2DM of relatively short duration, regardless of their glycaemic status. These observations support interventions that slow gastric emptying to improve postprandial glycaemia in these patients with T2DM.
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| http://dx.doi.org/10.1016/j.diabres.2020.108610 | DOI Listing |
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