AI Article Synopsis
- The study used the TOF-SIMS technique to analyze how terpinen-4-ol (TP4ol) and DMPBD form inclusion complexes with 2-hydroxypropyl-β-cyclodextrin (HPbCD) within human skin.
- TP4ol and DMPBD, key components of Zingiber cassumunar Roxb. (Plai) oil, accumulated in the epidermis and dermis, while without HPbCD, they couldn't penetrate the epidermis at all.
- This research opens up possibilities for further exploring the anti-inflammatory effects and potential use of these compounds for muscle pain relief.
Article Abstract
The distribution of terpinen-4-ol (TP4ol) and DMPBD inclusion complexes with 2-hydroxypropyl-β-cyclodextrin (HPbCD) in human skin has been investigated using the TOF-SIMS technique. TP4ol and DMPBD have been found to be major components of Zingiber cassumunar Roxb. (Plai) oil extracted by steam distillation. The results mainly show accumulation of TP4ol and DMPBD inclusion complexes with HPbCD in the epidermis and dermis whereas these two compounds without cyclodextrin cannot penetrate into the epidermis. This approach can be expanded for investigation of anti-inflammatory action and relief of muscle pain.
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| http://dx.doi.org/10.1039/d0ay02018d | DOI Listing |
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