AI Article Synopsis
- The sulfa-Michael addition process allows thiolates to react with enantiopure 2-sulfinyl dienes, producing 2-ene-1,4-hydroxy sulfides with high diastereoselectivity.
- The yields and selectivities of the reactions can be influenced by varying the reaction conditions, showcasing a diastereodivergent outcome.
- Additionally, these enantiopure hydroxy sulfides can be further utilized in synthetic applications through sigmatropic rearrangements.
Article Abstract
The highly diastereoselective sulfa-Michael addition of thiolates to enantiopure 2-sulfinyl dienes leads to or 2-ene-1,4-hydroxy sulfides in good yields and selectivities dependent on the reaction conditions in a diastereodivergent process. Synthetic applications of these enantiopure hydroxy sulfides by subsequent sigmatropic rearrangements have been outlined.
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| http://dx.doi.org/10.1021/acs.orglett.0c03929 | DOI Listing |
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