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[Common cause and mechanism for all pathologies of aging?]. | LitMetric

[Common cause and mechanism for all pathologies of aging?].

Med Sci (Paris)

Mediterranean Institute for Life Sciences (MedILS), Meštrovic΄evo šetalište 45, 21000 Split, Croatie - Naos Institute for Life Sciences, 355 rue Pierre-Simon Laplace, 13593 Aix-en-Provence, France - Inserm U1001, Université Paris-Descartes, Faculté de médecine Paris-Descartes, 24 rue du faubourg Saint-Jacques, 75014 Paris, France - Center of Excellence for Science and Technology-Integration of Mediterranean Region (STIM-REI), Interdisciplinary Center for Advanced Sciences and Technology (ICAST), Université de Split, Poljička cesta 35, 21000 Split, Croatie.

Published: December 2020

AI Article Synopsis

Article Abstract

Health is harmony, aging and its diseases (are) functional disharmony at the molecular, cellular and tissue levels. Our observations lead us to think that there seems to be a common cause and a common mechanism for aging and its many and diverse diseases. This common cause is the oxidative damage to particular proteins emerging from a combination of imperfect folding and oxidative stress. This common cause jointly goes with the biological clock common to various age-related diseases, whose the incidence increases exponentially over time and causes 90% of human mortality. Pharmacological interventions on the common cause could avoid and simultaneously attenuate all degenerative and malignant diseases, as it is the natural case of super-centenarians.

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Source
http://dx.doi.org/10.1051/medsci/2020221DOI Listing

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