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Interest-Activity Dimension and Response to Aripiprazole.
J Clin Psychiatry
December 2020
Department of Psychiatry, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India .
Symptom Dimension of Interest-Activity Indicates Need for Aripiprazole Augmentation of Escitalopram in Major Depressive Disorder: A CAN-BIND-1 Report.
J Clin Psychiatry
June 2020
Members of the CAN-BIND Investigator Team are listed at www.canbind.ca/about-can-bind/our-team/.
Objective: Differential predictors of response to alternative treatment options are needed to improve the outcomes in major depressive disorder. The symptom dimension comprising loss of interest and reduced activity has been reported as a predictor of poor outcome of treatment with antidepressants. We hypothesized that augmentation with partial dopamine agonist aripiprazole will be effective for individuals with pronounced interest-activity symptoms.
View Article and Find Full Text PDFCombining clinical variables to optimize prediction of antidepressant treatment outcomes.
J Psychiatr Res
July 2016
Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, 16 De Crespigny Park, Denmark Hill, London, SE5 8AF, UK; Dalhousie University Department of Psychiatry, 5909 Veterans' Memorial Drive, Halifax, B3H 2E2, Nova Scotia, Canada.
The outcome of treatment with antidepressants varies markedly across people with the same diagnosis. A clinically significant prediction of outcomes could spare the frustration of trial and error approach and improve the outcomes of major depressive disorder through individualized treatment selection. It is likely that a combination of multiple predictors is needed to achieve such prediction.
View Article and Find Full Text PDFDepression symptom dimensions as predictors of antidepressant treatment outcome: replicable evidence for interest-activity symptoms.
Psychol Med
May 2012
MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King's College London, UK.
Background: Symptom dimensions have not yet been comprehensively tested as predictors of the substantial heterogeneity in outcomes of antidepressant treatment in major depressive disorder.
Method: We tested nine symptom dimensions derived from a previously published factor analysis of depression rating scales as predictors of outcome in 811 adults with moderate to severe depression treated with flexibly dosed escitalopram or nortriptyline in Genome-based Therapeutic Drugs for Depression (GENDEP). The effects of symptom dimensions were tested in mixed-effect regression models that controlled for overall initial depression severity, age, sex and recruitment centre.
Changes in sexual attitudes and behavior patterns that might be associated with pregnancy and childbirth were investigated. The subjects were 216 women seen by a group of obstetricians and gynecologist in office practice. While there was a wide range of individual responses, in general a decline in sexual interest, activity, and satisfaction was reported as pregnancy progressed.
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