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Real-world outcomes of patients with locally advanced or metastatic epithelioid sarcoma. | LitMetric

AI Article Synopsis

  • Limited data shows that systemic therapies for advanced epithelioid sarcoma (ES) are minimally effective and come with significant side effects.
  • A study reviewing 74 patients indicated a real-world overall response rate of only 15% for first-line treatments and even lower for those receiving multiple lines of therapy.
  • Common adverse events included febrile neutropenia and pain, affecting over half of the patients, highlighting the challenges in treatment and management of this rare cancer.

Article Abstract

Background: Limited data are available on the real-world effectiveness and safety of systemic therapies for advanced (surgically unresectable and/or metastatic) epithelioid sarcoma (ES).

Methods: A retrospective medical records review was conducted in patients with advanced ES who were initiating first-line or ≥2 lines of systemic therapy (2000-2017) at 5 US cancer centers. The real-world overall response rate (rwORR), the duration of response (rwDOR), the disease control rate (rwDCR) (defined as stable disease for ≥32 weeks or any duration of response), and progression-free survival (rwPFS) were assessed by radiology reports. Overall survival (OS), rwDOR, and rwPFS were estimated from the time therapy was initiated using the Kaplan-Meier method. Serious adverse events were assessed.

Results: Of 74 patients (median age at diagnosis, 33 years; range, 10.6-76.3 years), 72% were male, and 85% had metastatic disease. The median number of lines of therapy was 2 (range, 1-7 lines of therapy), and 46 patients (62%) received ≥2 lines of systemic therapy. First-line regimens were usually anthracycline-based (54%) or gemcitabine-based (24%). For patients receiving first-line systemic therapy, the rwORR was 15%, the rwDCR was 20%, the median rwDOR was 3.3 months (95% CI, 2.1-5.2 months), the median rwPFS was 2.5 months (95% CI, 1.7, 6.9 months), and the median OS was 15.2 months (95% CI, 11.4-21.7 months). For those who received ≥2 lines of systemic therapy, the rwORR was 9%, the rwDCR was 20%, the median rwDOR was 4.5 months (95% CI, 0.7-5.6 months), and the median rwPFS was 6.0 months (95% CI, 3.2-7.4 months). Over one-half of patients (51.4%) experienced an adverse event, most frequently febrile neutropenia (14%), pain (10%), anemia, dyspnea, fever, thrombocytopenia, or transaminitis (5% each).

Conclusions: Systemic therapies demonstrate limited efficacy in patients with advanced ES and have associated toxicities.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8247010PMC
http://dx.doi.org/10.1002/cncr.33365DOI Listing

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