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Association between serum IgG antibody titers against and liver enzyme levels: A cross-sectional study in Sado Island. | LitMetric

Association between serum IgG antibody titers against and liver enzyme levels: A cross-sectional study in Sado Island.

Heliyon

Division of Periodontology, Department of Oral Biological Science, Faculty of Dentistry & Graduate School of Medical and Dental Sciences, Niigata University, 2-5274, Gakko-cho, Chuo-ku, Niigata, 951-8514, Japan.

Published: November 2020

AI Article Synopsis

Article Abstract

Background: Previous studies have reported associations between nonalcoholic fatty liver disease, periodontitis, and obesity. Serum immunoglobulin G (IgG) antibody titer against a major pathogen of periodontitis, is an established indicator of periodontal infection. However, the relationship between the antibody titer and liver enzyme levels has not been clarified yet. A study in the elderly was needed to evaluate the effect of long-term persistent bacterial infection on liver function. The objective of this study was to investigate the association between liver function and infection by and the effect of obesity on the association.

Methods: A cross-sectional study was conducted in adult outpatients visiting Sado General Hospital, in Niigata Prefecture, Japan, from 2008 to 2010. The final participants included 192 men and 196 women (mean age 68.1 years). Multivariable logistic regression analyses were performed to assess the association between the serum IgG antibody titer and the levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), and γ-glutamine transferase (GGT) levels.

Results: In women, serum IgG antibody titers against was associated with elevated ALT, but not with AST or GGT, independent of covariates (p = 0.015). No significant association was found between the antibody titer and the elevated liver enzymes in men. The effect of obesity on the relationship between antibody titer and liver enzyme levels was not statistically significant.

Conclusions: A cross-sectional analysis of adult outpatients suggested an association between infection and ALT levels in women. The effect of obesity on this association was not statistically significant.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7683334PMC
http://dx.doi.org/10.1016/j.heliyon.2020.e05531DOI Listing

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