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Unveiling the role of MDH1 in breast cancer drug resistance through single-cell sequencing and schottenol intervention.
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Department of Breast and Thyroid Surgery, The Qinghai Provincial People's Hospital, Xining 810007, China. Electronic address:
This study utilizes single-cell RNA sequencing data to reveal the transcriptomic characteristics of breast cancer and normal epithelial cells. Nine significant cell populations were identified through stringent quality control and batch effect correction. Further classification of breast cancer epithelial cells based on the PAM50 method and clinical subtypes highlighted significant heterogeneity between triple-negative breast cancer (TNBC) and non-triple-negative breast cancer (NTNBC).
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Department of Biodiversity Studies and Bioeducation, University of Lodz, Faculty of Biology and Environmental Protection, Banacha 1/3, Lodz 90-237, Poland.
There is a growing body of evidence that urbanization can affect body condition and immune function in wild birds, although these effects may be complex and taxa-specific. Here, we assessed the effects of urbanization on body condition (size-corrected body mass and haemoglobin concentration) and innate immune defences (haemolysis-haemagglutination assay, haptoglobin concentration and bacterial killing assay) in 136 Eurasian coots () from three urban and three non-urban populations across Poland. We also quantified the heterophil to lymphocyte ratio to control for the potential effect of physiological stress on immune defences.
View Article and Find Full Text PDFAssessment of MPOX infection-related knowledge levels, concerns, and associated factors: a community-based cross-sectional study.
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Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Dokuz Eylul University, İzmir, Türkiye.
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Section of Genetic Medicine, Department of Medicine, University of Chicago, Chicago, IL, USA.
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