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Bi+ Men's Explanations for Substance Use Disparities in Their Community.
J Bisex
July 2024
Department of Psychology, Rosalind Franklin University of Medicine and Science.
Bi+ men are more likely to use alcohol and drugs than heterosexual and often gay men. The minority stress model is the predominant framework for understanding these disparities, but it is unknown whether this framework is consistent with bi+ men's perspectives. As part of an online survey, 69 bi+ young men (ages 18-29; 29% transgender) were asked why they think bisexual men are more likely to use alcohol and drugs than other men (including gay men).
View Article and Find Full Text PDFDirected Evolution and Unusual Protonation Mechanism of Pyridoxal Radical C-C Coupling Enzymes for the Enantiodivergent Photobiocatalytic Synthesis of Noncanonical Amino Acids.
J Am Chem Soc
January 2025
Department of Chemistry and Biochemistry, University of California Santa Barbara, Santa Barbara, California 93106, United States.
Visible light-driven pyridoxal radical biocatalysis has emerged as a new strategy for the stereoselective synthesis of valuable noncanonical amino acids in a protecting-group-free fashion. In our previously developed dehydroxylative C-C coupling using engineered PLP-dependent tryptophan synthases, an enzyme-controlled unusual α-stereochemistry reversal and pH-controlled enantiopreference were observed. Herein, through high-throughput photobiocatalysis, we evolved a set of stereochemically complementary PLP radical enzymes, allowing the synthesis of both l- and d-amino acids with enhanced enantiocontrol across a broad pH window.
View Article and Find Full Text PDFAnalytical protocol for measuring micro-molar quantities of sulfur volatile species in experimental high pressure and temperature fluids.
Commun Chem
January 2025
Dipartimento di Scienze Della Terra, Università Degli Studi di Milano, via Mangiagalli 34, I-20133, Milano, Italy.
Validating thermodynamic models is essential in experimental geosciences for exploring increasingly complex systems and developing analytical protocols. However, investigating solid-fluid equilibria in mm-sized experimental capsules poses several challenges, particularly in sulfur-bearing chemical systems. These include maintaining bulk fluid composition and performing quantitative analysis with extremely low amounts of synthesized fluid.
View Article and Find Full Text PDFACOX1 activates autophagy via the ROS/mTOR pathway to suppress proliferation and migration of colorectal cancer.
Sci Rep
January 2025
Department of General Surgery, The First Affiliated Hospital of Soochow University, Suzhou, 215006, Jiangsu, China.
Acyl-CoA oxidase 1 (ACOX1), a member of the acyl-coenzyme A oxidase family, is considered a crucial regulator whose dysregulation is implicated in the occurrence and progression of various cancers. This study aims to elucidate the impact of ACOX1 in CRC, shedding light on its potential as a therapeutic target. Through analysis of the GEO dataset, it was found that ACOX1 is significantly downregulated in colorectal cancer (CRC), and this lower expression level is associated with a worse prognosis.
View Article and Find Full Text PDFDe novo transcriptome profiling revealing genes involved in piperine biosynthetic pathway in Piper longum L.
Sci Rep
January 2025
Plant Biotechnology Lab, Department of Botany, Faculty of Science, Dayalbagh Educational Institute (Deemed to be University), Dayalbagh, Agra, 282005, India.
Piper longum, commonly known as long pepper, is highly valued for its bioactive alkaloid piperine, which has diverse pharmaceutical and culinary applications. In this study, we used high-throughput sequencing and de novo transcriptome assembly to analyze the transcriptomes of P. longum leaves, roots, and spikes.
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