Isolation and characterization of Wad Medani virus obtained in the tuva Republic of Russia.

Ticks Tick Borne Dis

Chumakov Institute of Poliomyelitis and Viral Encephalitides FSBSI Chumakov FSC R&D IBP RAS, Moscow, Russia; Institute for Translational Medicine and Biotechnology, Sechenov First Moscow State Medical University, Moscow, Russia.

Published: March 2021

Wad Medani virus (WMV) belongs to the genus Orbivirus and is a poorly studied arbovirus with unclear medical significance. Presently, a limited number of WMV strains are characterized and available in NCBI GenBank, some isolated many years ago. A new WMV strain was isolated in 2012 from Dermacentor nuttalli ticks collected from sheep in the Tuva Republic, Russia, and sequenced using high-throughput methods. Complete coding sequences were obtained revealing signs of multiple intersegment reassortments. These point to a high variability potential in WMV that may lead to the formation of strains with novel properties. These new data on WMV can promote better understanding of: ecological features of its circulation; relationships within the genus Orbivirus; and the medical significance of the virus.

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http://dx.doi.org/10.1016/j.ttbdis.2020.101612DOI Listing

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