Neuroendocrine Differentiation of Skin Tumors: A Comprehensive Review.

Am J Dermatopathol

Professor, Dermatopathology Section, Department of Dermatology, Boston University School of Medicine, Boston, MA.

Published: December 2020

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Article Abstract

Neuroendocrine differentiation is characterized by endocrine and neuronal features with prominent dense secretory granules and neuropeptides. Neuroendocrine differentiation of skin tumors is of unknown clinical significance. Nonetheless, the acknowledgment of this line of differentiation is important to prevent diagnostic pitfalls and subsequent inappropriate management. This review aims at summarizing the skin neoplasms that can express neuroendocrine markers.

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http://dx.doi.org/10.1097/DAD.0000000000001664DOI Listing

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