AI Article Synopsis
- Pups from the inbred mouse strain RR/Sgn have low survival rates during rearing, with Naq3 identified as a quantitative trait locus affecting this survival.
- Researchers confirmed Naq3's impact in congenic mice and explored Vps8 as a potential candidate gene linked to Naq3.
- The study found that Vps8 expression is influenced by nurturing behaviors in wild-type mice and is significantly reduced in Naq3 congenic mice, suggesting Vps8's role in maternal nurturing.
Article Abstract
Pups born from females of the inbred mouse strain RR/Sgn tend to have low survival rates during rearing. We have previously identified Naq3, a quantitative trait locus underlying this low pup survival rate. In the present study, we confirmed the effect of Naq3 in congenic mice and investigated whether Vps8 is a candidate gene for Naq3. The survival rate of pups on the twelfth postpartum day was significantly decreased for mothers homozygous for the Naq3 allele. Hypothalamic expression of Vps8 was induced by nurturing in wild-type mice, and was significantly lower in Naq3 congenic mice than in wild-type mice. Thus, Vps8 is suggested to be involved in maternal nurturing, and therefore, as a plausible candidate gene for Naq3.
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| http://dx.doi.org/10.1111/cga.12406 | DOI Listing |
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