Motivated by a horse betting problem, a new conditional Rényi divergence is introduced. It is compared with the conditional Rényi divergences that appear in the definitions of the dependence measures by Csiszár and Sibson, and the properties of all three are studied with emphasis on their behavior under data processing. In the same way that Csiszár's and Sibson's conditional divergence lead to the respective dependence measures, so does the new conditional divergence lead to the Lapidoth-Pfister mutual information. Moreover, the new conditional divergence is also related to the Arimoto-Rényi conditional entropy and to Arimoto's measure of dependence. In the second part of the paper, the horse betting problem is analyzed where, instead of Kelly's expected log-wealth criterion, a more general family of power-mean utility functions is considered. The key role in the analysis is played by the Rényi divergence, and in the setting where the gambler has access to side information, the new conditional Rényi divergence is key. The setting with side information also provides another operational meaning to the Lapidoth-Pfister mutual information. Finally, a universal strategy for independent and identically distributed races is presented that-without knowing the winning probabilities or the parameter of the utility function-asymptotically maximizes the gambler's utility function.
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http://dx.doi.org/10.3390/e22030316 | DOI Listing |
Sci Rep
January 2025
School of Mathematics and Statistics, Shaoguan University, Shaoguan, 512005, China.
Recently, deep latent variable models have made significant progress in dealing with missing data problems, benefiting from their ability to capture intricate and non-linear relationships within the data. In this work, we further investigate the potential of Variational Autoencoders (VAEs) in addressing the uncertainty associated with missing data via a multiple importance sampling strategy. We propose a Missing data Multiple Importance Sampling Variational Auto-Encoder (MMISVAE) method to effectively model incomplete data.
View Article and Find Full Text PDFMethods Enzymol
January 2025
Natural Products Research Center, Chengdu Institute of Biology, Chinese Academy of Science, Chengdu, P.R. China. Electronic address:
As a promising therapeutic approach, the RNA editing process can correct pathogenic mutations and is reversible and tunable, without permanently altering the genome. RNA editing mediated by human ADAR proteins offers unique advantages, including high specificity and low immunogenicity. Compared to CRISPR-based gene editing techniques, RNA editing events are temporary, which can reduce the risk of long-term unintended side effects, making off-target edits less concerning than DNA-targeting methods.
View Article and Find Full Text PDFInt Immunopharmacol
January 2025
Department of Immunology, Mudanjiang Medical University, Mudanjiang, Heilongjiang 157011, China. Electronic address:
Objective: Aberrant 6-phosphofructo-2kinase/fructose-2,6-bisphoshatase 3 (PFKFB3) expression is tightly correlated with multiple steps of tumorigenesis; however, the pathological significance of PFKFB3 in macrophages in patients with rheumatoid arthritis (RA) remains obscure. In this study, we examined whether PFKFB3 modulates macrophage activation and promotes RA development.
Method: Peripheral blood mononuclear cells (PBMCs) from patients with RA, THP-1 cells, and bone marrow-derived macrophages from conditional PFKFB3-knockout mice were used to investigate the mechanism underlying PFKFB3-induced macrophage regulation of RA.
Int Immunopharmacol
January 2025
Guangdong Provincial Key Laboratory of Tumor Interventional Diagnosis and Treatment, Zhuhai Institute of Translational Medicine, Zhuhai People's Hospital (The Affiliated Hospital of Beijing Institute of Technology, Zhuhai Clinical Medical College of Jinan University), Jinan University, Zhuhai 519000, China; State Key Laboratory of Bioactive Molecules and Druggability Assessment, The Biomedical Translational Research Institute, Health Science Center (School of Medicine), Jinan University, Guangzhou 510632, China; Key Laboratory of Viral Pathogenesis & Infection Prevention and Control (Jinan University), Ministry of Education, Guangzhou 510632, China. Electronic address:
Previous studies have established that γδ T cells play a significant role in liver fibrosis. However, their specific functions and mechanisms in fibrotic liver tissue remain unclear. Using online microarray expression profiles, we observed that USF3 was upregulated in patients with liver fibrosis and was associated with immune cells.
View Article and Find Full Text PDFPLoS One
January 2025
Department of Horticulture and Landscape Architecture and Center for Rhizosphere Biology, Colorado State University, Fort Collins, Colorado, United States of America.
Root and rhizosphere studies often focus on analyzing single-plant microbiomes, with the literature containing minimum empirical information about the shared rhizosphere microbiome of multiple plants. Here, the rhizosphere of individual plants was analyzed in a microcosm study containing different combinations and densities (1-3 plants, 24 plants, and 48 plants) of cover crops: Medicago sativa, Brassica sp., and Fescue sp.
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