This tutorial paper focuses on the variants of the bottleneck problem taking an information theoretic perspective and discusses practical methods to solve it, as well as its connection to coding and learning aspects. The intimate connections of this setting to remote source-coding under logarithmic loss distortion measure, information combining, common reconstruction, the Wyner-Ahlswede-Korner problem, the efficiency of investment information, as well as, generalization, variational inference, representation learning, autoencoders, and others are highlighted. We discuss its extension to the distributed information bottleneck problem with emphasis on the Gaussian model and highlight the basic connections to the uplink Cloud Radio Access Networks (CRAN) with oblivious processing. For this model, the optimal trade-offs between relevance (i.e., information) and complexity (i.e., rates) in the discrete and vector Gaussian frameworks is determined. In the concluding outlook, some interesting problems are mentioned such as the characterization of the optimal inputs ("features") distributions under power limitations maximizing the "relevance" for the Gaussian information bottleneck, under "complexity" constraints.
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http://dx.doi.org/10.3390/e22020151 | DOI Listing |
Phys Chem Chem Phys
January 2025
Institute of Materials Research (IMR), Tsinghua Shenzhen International Graduate School, Tsinghua University, Shenzhen, 518055, China.
The molecular force field (FF) determines the accuracy of molecular dynamics (MD) and is one of the major bottlenecks that limits the application of MD in molecular design. Recently, artificial intelligence (AI) techniques, such as machine-learning potentials (MLPs), have been rapidly reshaping the landscape of MD. Meanwhile, organic molecular systems feature unique characteristics, and require more careful treatment in both model construction, optimization, and validation.
View Article and Find Full Text PDFNat Commun
January 2025
Institute for Quantum Inspired and Quantum Optimization, Hamburg University of Technology, Hamburg, Germany.
Estimation of the energy of quantum many-body systems is a paradigmatic task in various research fields. In particular, efficient energy estimation may be crucial in achieving a quantum advantage for a practically relevant problem. For instance, the measurement effort poses a critical bottleneck for variational quantum algorithms.
View Article and Find Full Text PDFTalanta
January 2025
State Key Laboratory of Component-based Chinese Medicine, Tianjin Key Laboratory of TCM Chemistry and Analysis, Tianjin University of Traditional Chinese Medicine, 10 Poyanghu Road, Jinghai District, Tianjin, 301617, PR China; Haihe Laboratory of Modern Chinese Medicine, Tianjin, 301617, PR China. Electronic address:
Metabolites identification is the major bottleneck in untargeted LC-MS metabolomics, primarily due to the limited availability of MS information for most detected metabolites in data dependent acquisition (DDA) mode. To solve this problem, we have integrated the iterative, interval, and segmented window acquisition concepts to develop an innovative non-fixed segmented window interval data dependency acquisition (NFSWI-DDA) mode, which achieves comparable MS coverage to data independent acquisition (DIA) mode. This acquisition strategy harnesses the strengths of both DDA and DIA, which could provide extensive coverage and excellent reproducibility of MS spectra.
View Article and Find Full Text PDFHum Brain Mapp
January 2025
Computational Radiology Laboratory, Department of Radiology, Boston Children's Hospital, and Harvard Medical School, Boston, Massachusetts, USA.
There is a growing interest in using diffusion MRI to study the white matter tracts and structural connectivity of the fetal brain. Recent progress in data acquisition and processing suggests that this imaging modality has a unique role in elucidating the normal and abnormal patterns of neurodevelopment in utero. However, there have been no efforts to quantify the prevalence of crossing tracts and bottleneck regions, important issues that have been investigated for adult brains.
View Article and Find Full Text PDFZhongguo Zhong Yao Za Zhi
December 2024
Sichuan Provincial Engineering Research Center of Formation Principle and Quality Evaluation of Genuine Medicinal Materials, Sichuan Engineering Technology Research Center of Genuine Regional Drug, Translational Chinese Medicine Key Laboratory of Sichuan Province, Key Laboratory of Biological Evaluation of TCM Quality of the State Administration of Traditional Chinese Medicine, Sichuan Institute for Translational Chinese Medicine Chengdu 610041, China.
Traditional Chinese medicine(TCM) resources refer to the total reserves of plants, animals, and minerals that can be used as raw materials of TCM(including Chinese medicial materials, TCM decoction pieces, TCM dispensing granules, traditional Chinese patent medicine, and TCM hospital preparation) and folk herbal medicine, which served as the material basis of inheritance, innovation, and development of TCM. In recent years, the sustainable utilization of TCM resources has received high attention and acquired a series of significant achievements in resource survey, quality evaluation, resource protection, innovative technology, and development and utilization, which effectively promoted the sustainable utilization of TCM resources and high-quality development of the TCM industry. The most urgent issue currently is to shift the focus of the research on the sustainable utilization of TCM resources from a sustainable utilization technology system to a sustainable utilization evaluation indicator system.
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