The evaluation of bed shear stress distribution is fundamental to predicting the transport of sediments and pollutants in rivers and to designing successful stable open channels. Such distribution cannot be determined easily as it depends on the velocity field, the shape of the cross section, and the bed roughness conditions. In recent years, information theory has been proven to be reliable for estimating shear stress along the wetted perimeter of open channels. The entropy models require the knowledge of the shear stress maximum and mean values to calculate the Lagrange multipliers, which are necessary to the resolution of the shear stress probability distribution function. This paper proposes a new formulation which stems from the maximization of the Tsallis entropy and simplifies the calculation of the Lagrange coefficients in order to estimate the bed shear stress distribution in open-channel flows. This formulation introduces a relationship between the dimensionless mean shear stress and the entropic parameter which is based on the ratio between the observed mean and maximum velocity of an open-channel cross section. The validity of the derived expression was tested on a large set of literature laboratory measurements in rectangular cross sections having different bed and sidewall roughness conditions as well as various water discharges and flow depths. A detailed error analysis showed good agreement with the experimental data, which allowed linking the small-scale dynamic processes to the large-scale kinematic ones.
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http://dx.doi.org/10.3390/e22010087 | DOI Listing |
Sci Rep
January 2025
University of Ulsan, 93 Daehak-ro, Nam-gu, Ulsan, 680-749, Republic of Korea.
This study employed large eddy simulation (LES) with the wall-adapting local eddy-viscosity (WALE) model to investigate transitional flow characteristics in an idealized model of a healthy thoracic aorta. The OpenFOAM solver pimpleFoam was used to simulate blood flow as an incompressible Newtonian fluid, with the aortic walls treated as rigid boundaries. Simulations were conducted for 30 cardiac cycles and ensemble averaging was employed to ensure statistically reliable results.
View Article and Find Full Text PDFSci Rep
January 2025
Department of Biomedical Engineering, University of Rochester, Rochester, NY, USA.
The aberrant vascular response associated with tendon injury results in circulating immune cell infiltration and a chronic inflammatory feedback loop leading to poor healing outcomes. Studying this dysregulated tendon repair response in human pathophysiology has been historically challenging due to the reliance on animal models. To address this, our group developed the human tendon-on-a-chip (hToC) to model cellular interactions in the injured tendon microenvironment; however, this model lacked the key element of physiological flow in the vascular compartment.
View Article and Find Full Text PDFJ Pharm Sci
January 2025
Laboratory of Functional Molecular Chemistry, Kobe Pharmaceutical University, 4-19-1, Motoyamakita-machi, Higashinada-ku, Kobe 658-8558, Japan.
Protein aggregation, a major concern in biopharmaceutical quality control, can be accelerated by various stresses during clinical handling. This study investigated potential aggregation risk factors during dilution process with syringe handling for intravenous administration. Using γ-globulin and IgG solutions as surrogate models of antibody therapeutics, we examined the effects of high sliding speeds and piston operations of the syringe on protein aggregation during saline dilution.
View Article and Find Full Text PDFMaterials (Basel)
January 2025
School of Engineering, Mackenzie Presbyterian University, São Paulo 01302-907, Brazil.
Ceramic detachments in cladding systems are indicative of adhesion loss between the ceramic tiles and the substrate or its adhesive mortar due to inadequate quality workmanship, the quality of the adhesive mortar or that of the ceramic material, whether acting simultaneously or not. The shear stresses resulting from the ceramic tiles' expansion due to humidity accelerate this process. There is a shortage of studies on the quality of ceramic tiles and adhesive mortars.
View Article and Find Full Text PDFMaterials (Basel)
January 2025
Department of Architecture and Civil Engineering, City University of Hong Kong, Hong Kong.
This paper investigates the effects of particle morphology (PM) and particle size distribution (PSD) on the micro-macro mechanical behaviours of granular soils through a novel X-ray micro-computed tomography (μCT)-based discrete element method (DEM) technique. This technique contains the grain-scale property extraction by the X-ray μCT, DEM parameter calibration by the one-to-one mapping technique, and the massive derivative DEM simulations. In total, 25 DEM samples were generated with a consideration of six PSDs and four PMs.
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