Alb29, an α-oxoamine synthase involved in albogrisin biosynthesis in MGR072, was characterized and responsible for the incorporation of l-glutamate to acyl-coenzyme A substrates. Combined with Alb29 and Mgr36 (an acyl-coenzyme A ligase), a one-pot enzymatic system was established to synthesize seven α-amino ketones. When these α-amino ketones were fed into the knockout strain Δ, respectively, the albogrisin analogs with different side chains were observed.
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| http://dx.doi.org/10.1021/acs.orglett.0c03600 | DOI Listing |
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