AI Article Synopsis
- Triple-negative breast cancer (TNBC) is aggressive due to its ability to migrate, and the study examines afzelin, a chemical compound thought to inhibit this migration.
- The research involved building a protein database related to cell movement, identifying druggable proteins, and assessing afzelin's inhibitory effects compared to known inhibitors.
- Ten proteins were identified as potential targets for afzelin, with ERK2, KRas, and FAK being the most promising, suggesting that afzelin may effectively reduce TNBC cell movement.
Article Abstract
Background: Triple-negative breast cancer (TNBC) tends to be aggressive and metastatic, characteristics attributable to its cellular migration capabilities. Afzelin is a chemical compound with anti-metastatic potentials. This study aimed to predict proteins involved in TNBC cell migration which could be inhibited by afzelin.
Methods: The protein database was constructed from the Kyoto Encyclopedia of Genes and Genomes pathways collection which related to cell motility, then screened for druggability using SuperTarget and Therapeutic Target Database. The involvement of druggable proteins in the TNBC metastasis process was investigated through existing publications in The National Center for Biotechnology Information PubMed database. Inhibitory potential of afzelin toward target proteins was compared to the proteins' known-inhibitor, using the reverse docking method.
Results: Ten proteins identified as potential targets of afzelin, with the top 3 being ERK2, KRas, and FAK, respectively. Afzelin's 3-O-rhamnoside group played a dominant role in forming hydrogen bonds with the target proteins. Further analysis with STRING suggested that afzelin might be able to inhibit chemotaxis and haptotaxis of TNBC cells.
Conclusions: Afzelin was predicted to inhibit TNBC cell motility, by targeting ERK2, KRas, and FAK activation.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7710241 | PMC |
| http://dx.doi.org/10.1097/j.pbj.0000000000000095 | DOI Listing |
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