Introduction: Podocytes play a crucial role in health and disease. They participate in clearing the filtration barrier by removing accumulated proteins. It is proposed that podocytes have the ability to remove immune complexes and internalize them in the cytoplasm.
Aims: The purpose of this study is to review certain immune complex glomerulonephritis (GN) types and illustrate ultrastructural details of podocytes intracytoplasmic dense inclusions (ICDIs) if present.
Materials And Methods: A retrospective ultrastructural study of podocytes was conducted to detect cytoplasmic inclusions. The study cases ( = 148) include GN types with subepithelial dense deposits such as membranous GN, postinfectious GN (PIGN), and lupus nephritis.
Results: Podocytes ICDIs are detected ultrastructurally in 48 of 148 cases, mostly with PIGN; their morphology resembles the subepithelial dense deposits of the corresponding case.
Conclusions: Podocytes ICDIs represent internalized immune complexes from the adjacent subepithelial dense deposits, suggesting a clearance method of the glomerular basement membrane by podocytes.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7703013 | PMC |
| http://dx.doi.org/10.4103/JMAU.JMAU_66_19 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Significant response to tocilizumab in a case of immune deposits-related membranoproliferative glomerulonephritis and tubulointerstitial nephritis complicated by multicentric Castleman's disease.
Clin Nephrol Case Stud
December 2024
Nephrology Center and the Okinaka Memorial Institute for Medical Research.
A 47-year-old woman with a 12-year history of anemia and high C-reactive protein (CRP) levels was admitted to our hospital with worsening fatigue and night sweats. She had high levels of immunoglobulin G (IgG; 4182 mg/dL), IgA (630.6 mg/dL), and CRP (7.
View Article and Find Full Text PDFA Case of Membranous Nephropathy Associated with Syphilis: Correlative Light and Electron Microscopy Revealing the Localization of Neuron-derived Neurotrophic Factor within Subepithelial Electron Dense Deposits.
Intern Med
December 2024
Division of Nephrology, Endocrinology and Metabolism, Department of Internal Medicine, Keio University School of Medicine, Japan.
A 50-year-old man presented to our hospital with a fever, edema, and a rash. The clinical diagnosis was renal dysfunction, nephrotic syndrome, and syphilis. The patient was treated with benzylpenicillin, and his symptoms improved.
View Article and Find Full Text PDFParvovirus B19-related membranoproliferative glomerulonephritis presenting with positive glomerular staining for nephritis-associated plasmin receptor: a case report and review of the literature.
CEN Case Rep
December 2024
Department of Nephrology, Kitasato University School of Medicine, 1-15-1 Kitasato, Minami, Sagamihara, Kanagawa, 252-0375, Japan.
Several cases of glomerulonephritis occurring after infection with human parvovirus B19 (PVB19) have been reported. However, the pathogenesis and clinicopathological features of PVB19-related glomerulonephritis remain elusive. We describe the case of a 34 year-old woman who showed nephrotic syndrome and microscopic hematuria 10 days after PVB19 infection.
View Article and Find Full Text PDFStudy of the Correlation between the Extent and Clinical Severity, and the Histopathological Characteristics of Geographic Tongue.
Folia Morphol (Warsz)
November 2024
Postgraduate Program in Dentistry, Health Institute of Nova Friburgo, Fluminense Federal University, Nova Friburgo, Brazil.
Article Synopsis
- - The study investigates the relationship between the Geographic Tongue Area and Severity Index (GTASI) scores and the histopathological features of geographic tongue lesions, an oral condition with unclear causes.
- - Conducted with 40 participants, the results show that 60% had mild cases, with common histological traits observed, such as parakeratosis and basal layer hyperplasia, regardless of severity levels.
- - Findings indicate that while mild cases exhibit low inflammatory response, more severe cases show distinct histopathological features, suggesting a strong link between the clinical severity of geographic tongue and its histological characteristics.
Subclinical acute tubular necrosis potentially associated with red yeast rice consumption unexpectedly detected in a patient with membranous nephropathy.
CEN Case Rep
November 2024
Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan.
Article Synopsis
- In March 2024, a public health issue in Japan linked red yeast rice supplements to kidney problems, including nephrotic syndrome in a 74-year-old man.
- The man's condition was diagnosed as membranous nephropathy, confirmed by specific immunostaining, and potentially triggered by the supplement he was taking.
- The case suggests that even asymptomatic individuals consuming red yeast rice products could have underlying kidney damage, highlighting that the reported health risks may not fully encompass the potential dangers.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!