The present study was an investigation of the neuroprotective effects of probiotic bacteria in SH-SY5Y neuroblastoma cells experiencing oxidative stress. The bacterial strains were: commercial GG; two isolated bacterial strains ( KU200170 and KU200661); and probiotic KC24. To evaluate the neuroprotective effects of the bacteria, a conditioned medium (CM) was prepared using HT-29 cells cultured with the heat-killed probiotic strains. Of the bacterial strains tested, the oxidatively stressed SH-SY5Y cells were most viable when cultured with KC24-CM. KC24-CM promoted the expression of brain-derived neurotropic factor () in the HT-29 cells. It also significantly increased expression and reduced the apoptosis-related ratio in the oxidatively stressed SH-SY5Y cells. Therefore, KC24 is a potential psychobiotic for use in the functional food industry.
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| http://dx.doi.org/10.1007/s10068-020-00830-7 | DOI Listing |
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