Background: To improve periprocedural outcomes of transcatheter aortic valve implantation (TAVI), transcatheter mechanical resection devices were tested for prior ablation of the aortic cusps.
Methods: Three mechanical transcatheter resection devices were tested in a series of native porcine (n=30) and reassembled calcified human valves (n=54). The resection time, the resected valve area, the number of released cusps, and the degree of surrounding tissue damage were measured. Afterwards, postmortem transapical-transcatheter-resections of the aortic valve in two humans were performed.
Results: In the native porcine hearts, the Aesculap II device demonstrated significantly shorter resection time compared to the R&R II and the Randstad devices (6.5±2.0 28.6±24.1 23.3±14.4 sec; P=0.001). However, it created more lesions in the surrounding tissue (P=0.002). The R&R II achieved a smaller number of resected cusps than the other two devices (2.7±0.7 1.1±0.7 2.4±0.5; P<0.001, respectively). It also resected a smaller area of the aortic valve (306.5±149.2 106.7±29.6 256.8±81.3 mm2; P=0.09) but a larger mean area of the resected fragments (110.3±41.5 160.7±29.6 111.5±43.9 mm2; P=0.01). The resection of the reassembled human valves demonstrated the same results between the devices regarding resection time (P=0.001) and resected area (P=0.016), but not fragment sizes (P=0.610). Finally, transapical-transcatheter-resection of aortic valve was performed in two cadavers.
Conclusions: Transcatheter aortic valve resection is feasible with variable aortic leaflet resection times and mild risk of lesions of the surrounding tissue.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7711357 | PMC |
http://dx.doi.org/10.21037/jtd-20-2036 | DOI Listing |
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