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Quantitative sizing of microplastics up to 20 µm using ICP-TOFMS.
J Anal At Spectrom
January 2025
ETH Zurich, Department of Chemistry and Applied Biosciences Vladimir-Prelog-Weg 1 8093 Zurich Switzerland
A fundamental study of four different sample introduction systems was carried out to evaluate the upper size limit of microplastics measured by inductively coupled plasma-time-of-flight-mass spectrometry (ICP-TOFMS). Three different, certified microplastic samples (PS, PMMA and PVC) within a size range of 3-20 µm in suspension were measured. In this study, no particles larger than 10 µm could be detected using pneumatic nebulization for sample introduction.
View Article and Find Full Text PDFImpact of pneumatic tube transportation on the aggregation of monoclonal antibodies in clinical practice.
Eur J Pharm Sci
January 2025
Laboratory of General Biochemistry and Physical Pharmacy, Ghent University, Ottergemsesteenweg 460, 9000 Ghent, Belgium; Biopharmaceutical Technology, TUM School of Life Sciences, Technical University of Munich, Emil-Erlenmeyer-Forum 5, 85354 Freising, Germany. Electronic address:
Postproduction handling and in-hospital transportation of antibody drugs cause mechanical stress, including interfacial and shear stress, that can induce antibody unfolding and aggregation. The handling practices differ significantly between hospitals and the impact on protein stability is unknown. For example, the mechanical stress caused by transport via pneumatic tube systems (PTS) on therapeutic antibody aggregation is a potential safety and quality gap.
View Article and Find Full Text PDFManual flagging failed to identify pseudohyperkalemia in acute myeloid leukemia: case report.
Int J Emerg Med
October 2024
Division of Nephrology, Department of Internal Medicine, UCSF Fresno Center for Medical Education and Research, 155 N Fresno St, Fresno, CA, 93701, USA.
Article Synopsis
- Pseudohyperkalemia, often seen in chronic lymphocytic leukemia, is rare in acute myeloid leukemia (AML), but can pose diagnostic challenges, as shown in a case involving a 55-year-old man with severe leukocytosis and falsely elevated potassium levels.
- Despite the lab's manual flagging system meant to identify such cases, it failed to function properly, leading to reliance on clinicians' instincts for the correct diagnosis of pseudohyperkalemia.
- The incident was linked to pneumatic tube transport of blood samples, prompting the lab to consider enhancements in its flagging system and the importance of using whole blood for potassium measurements in cases of significant leukocytosis.
Endoscopic Management of Dysfunctioning Gastric Band after Sleeve Gastrectomy with the Luso-Cor Esophageal Stent.
GE Port J Gastroenterol
October 2024
Serviço de Gastrenterologia e Hepatologia, Centro Hospitalar Universitário Lisboa Norte, Lisboa, Portugal.
Article Synopsis
- A 58-year-old woman experienced complications, including regurgitation and obstruction, after her SG and subsequent ring placement, necessitating a two-step endoscopic procedure with a new Luso-Cor esophageal stent for treatment.
- After initial unsuccessful attempts to alleviate symptoms through dilatation, the stent was ultimately removed, revealing a partially eroded calibration ring, and the patient reported being asymptomatic afterward, leading to a conservative follow-up approach.
Fast, variable stiffness-induced braided coiled artificial muscles.
Proc Natl Acad Sci U S A
October 2024
School of Mechanical Engineering, Yangzhou University, Yangzhou 225127, PR China.
Article Synopsis
- The study introduces a new type of biomimetic muscle that works by changing stiffness through volume expansion, made from a coiled braid with a hollow elastomer tube inside.
- This synthetic muscle can contract by 47.3% and achieve a maximum power density of 3.0 W/g with a mechanical efficiency of 74% when stimulated by air pressure.
- It operates at low pressure, allowing for portable actuation and features bipolar actuation, making it suitable for use in fast-running and climbing robots.
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