In the quest for the physical substrate of learning and memory, a consensus gradually emerges that memory traces are stored in specific neuronal populations and the synaptic circuits that connect them. In this review, we discuss recent progresses in understanding the reorganization of synaptic circuits and neuronal assemblies associated with learning and memory, with an emphasis on optical techniques for in vivo interrogations. We also highlight some open questions on the missing link between synaptic modifications and neuronal coding, and how stable memory persists despite synaptic and neuronal fluctuations.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8172648 | PMC |
| http://dx.doi.org/10.1016/j.conb.2020.10.015 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Multi-region processing during sleep for memory and cognition.
Proc Jpn Acad Ser B Phys Biol Sci
March 2025
Laboratory for Sleeping-Brain Dynamics, Research Center for Idling Brain Science, University of Toyama, Toyama, Japan.
Over the past decades, the understanding of sleep has evolved to be a fundamental physiological mechanism integral to the processing of different types of memory rather than just being a passive brain state. The cyclic sleep substates, namely, rapid eye movement (REM) sleep and non-REM (NREM) sleep, exhibit distinct yet complementary oscillatory patterns that form inter-regional networks between different brain regions crucial to learning, memory consolidation, and memory retrieval. Technical advancements in imaging and manipulation approaches have provided deeper understanding of memory formation processes on multi-scales including brain-wide, synaptic, and molecular levels.
View Article and Find Full Text PDFTimosaponin AⅢ inhibits ectopic lipid deposition and enhances the browning of white adipose tissue.
Eur J Pharmacol
March 2025
School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China. Electronic address:
Timosaponin AⅢ(TAⅢ), derived from the Chinese medicinal herb Anemarrhena asphodeloides Bunge, has been reported to have a range of pharmacological effects including improvement of learning and memory deficits, anti-tumor, hypoglycemic effect and anti-hypertension. This study explored the therapeutic effects and preliminary mechanisms of TAⅢ in improving insulin resistance in ob/ob mice. We found that treatment with 10 mg·kg·d of TAⅢ reduced the expression of SREBPs and alleviated ectopic lipid deposition by decreasing DAG accumulation in liver.
View Article and Find Full Text PDFLancao decoction alleviates Alzheimer's disease: depending on activating CaMKII to protect neuronal refunction by reducing β-amyloid in the hippocampus.
J Ethnopharmacol
March 2025
Interdisciplinary Institute for Personalized Medicine in Brain Disorders, Jinan University, School of Chinese medicine, Guangzhou, 510632, China; f GHM Joint Laboratory of Traditional Chinese Medicine on Brain-Peripheral Homeostasis and Comprehensive Health, Jinan University, School of Chinese medicine, Guangzhou, 510632, China; Zhuhai Institute of Jinan University, Zhuhai, 519070, China. Electronic address:
Ethnopharmacological Relevancy: Lancao decoction (LC) is a traditional Chinese medicine (TCM) formulation mentioned in the "Huangdineijing", known for its ability to dispel turbidity and eliminate heat. TCM believes that the etiology of Alzheimer's disease (AD) is phlegm turbidity, and the fiery internal obstruction of the gods, which suggests that LC has the possibility of treating.
Aim Of The Study: This investigation will examine the possibilities of LC to improve AD and uncover the underlying mechanisms.
Reward prediction-error promotes the neural encoding of episodic learning.
Neuropsychologia
March 2025
Department of Psychology, Institute of Education, China West Normal University, Nanchong 637002.
Reward prediction-error carries significant implications for learning, facilitating the process by influencing prior knowledge and shaping future expectations and decisions. However, the electrophysiological mechanism through which reward prediction-error impacts learning remains incompletely understood. This study aimed to investigate the neural characteristics of reward prediction-error and its effect on recognition memory using Event-Related Potentials (ERPs).
View Article and Find Full Text PDFProtective effects of anthocyanins on the nervous system injury caused by fluoride-induced endoplasmic reticulum stress in rats.
Food Chem Toxicol
March 2025
Center for Endemic Disease Control, Chinese Center for Disease Control and Prevention, Harbin Medical University, Harbin, Heilongjiang 150081, China; Key Lab of Etiology and Epidemiology, Education Bureau of Heilongjiang Province & Ministry of Health (23618504), Harbin Medical University, Harbin 150081, China; Heilongjiang Provincial Key Lab of Trace Elements and Human Health Harbin Medical University, Harbin 150081, China. Electronic address:
Long-term fluoride exposure can produce neurotoxicity. Anthocyanins, as antioxidants, have a certain protective effect in nerve damage. This study aimed to investigate the protective role of anthocyanins in fluoride-induced neurological damage due to endoplasmic reticulum stress (ERS).
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!