AI Article Synopsis
- The human gut houses a vast number of bacteria and fungi, and gut dysbiosis is linked to the development of colorectal cancer (CRC).
- Recent studies indicate that disruptions in fungal populations also play a role in CRC progression.
- The review discusses fungal dysbiosis's impact on CRC, potential tumor-causing mechanisms of fungi, and suggests therapeutic strategies to target fungal communities for better CRC management.
Article Abstract
The human gut is mainly habited by a staggering amount and abundance of bacteria as well as fungi. Gut dysbiosis is believed as a pivotal factor in colorectal cancer (CRC) development. Lately increasing evidence from animal or clinical studies suggested that fungal disturbance also contributed to CRC development. This review summarized the current status of fungal dysbiosis in CRC and highlighted the potential tumorigenic mechanisms of fungi. Then the fungal markers and some therapeutic strategies for CRC were discussed. It would provide a better understanding of the correlation of mycobiota and CRC, and modulating fungal community would be a promising target against CRC.
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| http://dx.doi.org/10.1016/j.bbcan.2020.188489 | DOI Listing |
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