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Nephroblastoma in a Sprague Dawley rat unrelated to titanium dioxide nanoparticle exposure in utero. | LitMetric

Nephroblastoma in a Sprague Dawley rat unrelated to titanium dioxide nanoparticle exposure in utero.

Vet Med Sci

Department of Pathobiology and Diagnostic Investigation, College of Veterinary Medicine, Michigan State University, East Lansing, MI, USA.

Published: May 2021

AI Article Synopsis

Article Abstract

Nephroblastoma is an embryonal tumour that has rarely been reported in laboratory rats. In this case report, a large nephroblastoma with peritoneal seeding was found during necropsy in an 11-month-old, female, Sprague Dawley rat. The rat had a history of indirect exposure to nano-TiO (titanium dioxide nanoparticles) during maternal gestation. A firm mass in the upper right abdominal quadrant was palpated. Four weeks later, the animal quickly declined. Nephroblastoma was confirmed by histopathology. Only one rat developed nephroblastoma among the ten littermates. Nephroblastomas in Sprague Dawley rats are typically spontaneous tumours with non-malignant mesenchymal elements. The capability to induce a nephroblastoma with nano-TiO is less likely in this case.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8136948PMC
http://dx.doi.org/10.1002/vms3.405DOI Listing

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