Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7935751 | PMC |
| http://dx.doi.org/10.1093/clinchem/hvaa240 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Intrahepatic levels of microbiome-derived hippurate associates with improved metabolic dysfunction-associated steatotic liver disease.
Mol Metab
December 2024
University of Lille, Lille University hospital, 59045, Lille, France; INSERM U1283, CNRS UMR 8199, Institut Pasteur de Lille, 59045, Lille, France; Division of Systems Medicine, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, W12 0NN, United Kingdom; The Victor Phillip Dahdaleh Institute of Genomic Medicine, McGill University, Montréal, H3A 0G1, Canada. Electronic address:
Objective: Metabolic dysfunction-associated steatotic liver disease (MASLD) is characterised by lipid accumulation in the liver and is often associated with obesity and type 2 diabetes. The gut microbiome recently emerged as a significant player in liver metabolism and health. Hippurate, a host-microbial co-metabolite has been associated with human gut microbial gene richness and with metabolic health.
View Article and Find Full Text PDFThe Association Between Serum Trimethylamine -Oxide and Arterial Stiffness in Chronic Peritoneal Dialysis Patients: A Cross-Sectional Study.
Toxins (Basel)
December 2024
Institute of Medical Sciences, Tzu Chi University, Hualien 97004, Taiwan.
Trimethylamine -oxide (TMAO), a gut microbiome-derived metabolite, participates in the atherogenesis and vascular stiffening that is closely linked with cardiovascular (CV) complications and related deaths in individuals with kidney failure undergoing peritoneal dialysis (PD) therapy. In these patients, arterial stiffness (AS) is also an indicator of adverse CV outcomes. This study assessed the correlation between serum TMAO concentration quantified with high-performance liquid chromatography and mass spectrometry and central AS measured by carotid-femoral pulse wave velocity (cfPWV) in patients with chronic PD.
View Article and Find Full Text PDFIntegrated analysis of microbiome and metabolome reveals signatures in PDAC tumorigenesis and prognosis.
Microbiol Spectr
November 2024
Department of General Surgery, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China.
Article Synopsis
- This study investigates the link between the microbiome and metabolic substances in pancreatic ductal adenocarcinoma (PDAC) through an analysis of tissue samples from 105 patients over six years.
- Findings reveal decreased microbial diversity in PDAC tumors compared to normal adjacent tissues, with specific opportunistic pathogens linked to poorer overall survival outcomes.
- The metabolomic analysis identified 553 unique metabolites differentiating PDAC from normal tissues, suggesting that microbiota may influence PDAC development by modulating certain metabolic pathways.
Microbiome-derived metabolites in early to mid-pregnancy and risk of gestational diabetes: a metabolome-wide association study.
BMC Med
October 2024
Division of Research, Kaiser Permanente Northern California, Pleasanton, CA, 94536, USA.
Article Synopsis
- Researchers studied the link between microbiome-derived metabolites and the risk of gestational diabetes (GDM) during early to mid-pregnancy in a diverse population, highlighting how these metabolites might play a role in diabetes risk.
- The study included a total of 91 GDM and 180 non-GDM participants in its discovery phase and validated the findings with additional groups, using advanced metabolomic techniques to analyze serum samples.
- Findings suggested that certain metabolites, particularly carbocyclic acids and branched-chain amino acids, were significantly associated with GDM risk, and a predictive model combining these metabolites with conventional risk factors proved to be more effective in identifying GDM risk than traditional methods alone.
Quantification of gut microbiome metabolites using chemical isotope derivatization strategy combined with LC-MS/MS: Application in neonatal hypoxic-ischemic encephalopathy rat model.
J Pharm Biomed Anal
September 2024
Microbiome Medicine Centre, Guangdong Provincial Clinical Research Center for Laboratory Medicine, Department of Laboratory Medicine, Zhujiang Hospital, Southern Medical University Guangzhou, Guangdong 510280, China. Electronic address:
The gut microbiome plays pivotal roles in various physiological and pathological processes, with key metabolites including short chain fatty acids (SCFAs), bile acids (BAs), and tryptophan (TRP) derivatives gaining significant attention for their diverse physiological roles. However, quantifying these metabolites presents challenges due to structural similarity, low abundance, and inherent technical limitations in traditional detection methods. In this study, we developed a precise and sensitive liquid chromatography-tandem mass spectrometry (LC-MS/MS) method utilizing a chemical isotope derivatization technique employing 4-(aminomethyl)-N,N-dimethylaniline-d/d (4-AND-d/d) reagents to quantify 37 typical gut microbiome-derived metabolites.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!