In our recently published meta-analysis, due to an oversight, we treated urinary As concentration data reported by Tsinovoi et al [...].
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Endoscopic Screening for Laryngotracheal Complications in Children Following Prolonged Mechanical Ventilation Maintained Through Endotracheal Intubation: A Cross-Sectional Pilot Project.
Ann Otol Rhinol Laryngol
December 2024
Department of Otorhinolaryngology & Head-Neck Surgery, Medical College & Hospital, Kolkata; West Bengal, India.
Background: An endoscopic screening program following successful weaning from prolonged mechanical ventilation maintained through endotracheal tube (ET; ) may be justified to assess the upper (laryngotracheal) airway in children who may not always be symptomatic for intubation-related complications.
Objectives: To evaluate effects of prolonged intubation in children through endoscopic screening of the laryngotracheal airway.
Methods: In this cross-sectional pilot project, children (2 months-12 years) successfully extubated following prolonged intubation were selected, irrespective of having symptoms, for a 1-time flexible nasolaryngoscopy at third to sixth month post-extubation (follow-up window).
A large language model in solving primary healthcare issues: A potential implication for remote healthcare and medical education.
J Educ Health Promot
September 2024
Department of Physiology, All India Institute of Medical Sciences, Deoghar, Jharkhand, India.
Background And Aim: Access to quality health care is essential, particularly in remote areas where the availability of healthcare professionals may be limited. The advancement of artificial intelligence (AI) and natural language processing (NLP) has led to the development of large language models (LLMs) that exhibit capabilities in understanding and generating human-like text. This study aimed to evaluate the performance of a LLM, ChatGPT, in addressing primary healthcare issues.
View Article and Find Full Text PDFPhotoredox Activation of Donor-Acceptor Cyclopropanes: Distonic Radical Cation Reactivity in [3+2] Cycloaddition Reactions.
Angew Chem Int Ed Engl
December 2024
Department of Chemistry and Chemical Biology, Indian Institute of Technology (ISM) Dhanbad, Jharkhand, 826004, India.
Article Synopsis
- Altering the reactivity of molecules could resolve current limitations, especially for Donor-Acceptor Cyclopropanes (DACs) which have relied on Lewis acids for activation.
- Unpolarized alkenes present challenges due to a polarity mismatch with the Lewis acid-mediated zwitterionic intermediate, hindering their coupling.
- Using photoredox catalysis to leverage the distonic radical cation approach successfully navigates this mismatch, allowing for the formation of highly substituted cyclopentanes and facilitating new pathways to create bicyclo[3.1.1]heptanes through a unique [3σ+2σ] cycloaddition process.
A clinicoepidemiological study of serologically diagnosed acute febrile illness in a teaching hospital, Kolkata.
J Family Med Prim Care
October 2024
Department of Microbiology, Nil Ratan Sircar Medical College and Hospital, Kolkata, West Bengal, India.
Introduction: Similar presenting manifestations in early phase and lack of awareness of aetiology of acute febrile illness (AFI) are major challenges in management of AFI.
Material And Methods: This was a retrospective observational cross-sectional study conducted in the Department of Microbiology, NRS Medical College, from 1 July 2022 to 30 June 2023 in serologically diagnosed febrile patients attending the outpatient department or admitted. Clinical and epidemiological data and laboratory parameters were recorded in a pretested structured questionnaire study tool, and collected data were analysed on MS-Excel sheets with various charts and tables.
RNA-Puzzles Round V: blind predictions of 23 RNA structures.
Nat Methods
December 2024
GMU-GIBH Joint School of Life Sciences, The Guangdong-Hong Kong-Macao Joint Laboratory for Cell Fate Regulation and Diseases, Guangzhou National Laboratory, Guangzhou Medical University, Guangzhou, China.
Article Synopsis
- - RNA-Puzzles is a collaborative project focused on improving the prediction of RNA three-dimensional structures, with predictions made by modeling groups before experimental structures are published.
- - A significant set of predictions was made by 18 groups for 23 different RNA structures, including various elements like ribozymes and aptamers.
- - The study highlights key challenges in RNA modeling, such as identifying helix pairs and ensuring proper stacking, and notes that some top-performing groups also excelled in a separate competition (CASP15).
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