Expression of ATP/GTP Binding Protein 1 Has Prognostic Value for the Clinical Outcomes in Non-Small Cell Lung Carcinoma.

ATP/GTP binding protein 1 () encodes a crucial protein, cytosolic carboxypeptidase 1 (CCP1), which plays a role in modulating the polyglutamylation of tubulin and has been studied in degenerative diseases. However, the role of in malignancy has not been completely studied yet. In this study, we examined the role of in cancer progression, its association with patient survival, and related mechanisms in lung cancer, using the A549 cell line and lung cancer gene expression datasets. knockdown increased the proliferation, migration, sphere formation, and drug resistance of A549 cells. Lung cancer datasets revealed significantly lower mRNA and protein expression levels of in lung cancer tissues, as compared to those in normal tissues. Importantly, expression positively correlated with patient survival. Analysis of co-expressed genes revealed that expression positively correlated with immune infiltration in lung cancer. Our results conclusively suggested that expression was correlated with cancer progression and immune infiltration in lung cancer.