Microfibers (MFs) have recently become an increasingly prevalent pollutant in ecosystems and pose a direct threat to organisms and an indirect threat via adsorption of other pollutants. Here, we used Caenorhabditis elegans to study multigenerational effects of polyethylene terephthalate (PET) MFs (diameter 17.4 μm) by observing the maternal generation (P0) to the seventh offspring generation (F7) with continuous MF exposure. Exposure to 250-μm PET MFs decreased locomotion behavior and induced intestinal reactive oxygen species (ROS) in the P0 generation compared with other PET MF sizes. Moreover, no notably negative effects on survival were observed in any generation during continuous exposure to 250-μm PET MFs. However, the reproduction rate clearly decreased in the F2 and F3 generations but gradually recovered in the F4-F7 generations. Developmental abnormalities showed a close relationship with body length. Although some recovery was confirmed, there were significant decreases in body length in the F2-F5 generations. Interestingly, growth inhibition was also observed in the F6 generation without MF exposure. ROS production and dermal damage in the P0-F5 generations might have resulted in the toxicological responses. To the best of our knowledge, this is the first study to provide evidence of multigenerational toxicity of MFs in C. elegans.
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.1016/j.envres.2020.110569 | DOI Listing |
Eur Urol Focus
November 2024
Department of Radiation Oncology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland. Electronic address:
Background And Objective: Up to 50% of patients with prostate cancer experience prostate-specific antigen (PSA) relapse following primary radical prostatectomy (RP). Prostate-specific membrane antigen (PSMA) positron emission tomography (PET) is increasingly being used for staging after RP owing to its high detection rate. Our aim was to compare outcomes for patients who received salvage radiotherapy (sRT) with versus without PSMA PET guidance.
View Article and Find Full Text PDFCancers (Basel)
August 2024
Department of Clinical Oncology, Pamela Youde Nethersole Eastern Hospital, Hong Kong, China.
This study retrospectively evaluates the clinical outcomes of definitive volumetric modulated arc therapy (VMAT) for high-risk or very high-risk locoregional prostate cancer patients from an Asian institution. Consecutive patients who received VMAT (76 Gy in 38 fractions) between January 2017 and June 2022 were included. Whole pelvic radiotherapy (WPRT) (46 Gy in 23 fractions) was employed for clinically node-negative disease (cN0) and a Roach estimated risk of ≥15%, as well as simultaneous integrated boost (SIB) of 55-57.
View Article and Find Full Text PDFClin Oncol (R Coll Radiol)
December 2024
Department of Radiotherapy, Clatterbridge Cancer Centre, 65 Pembroke Place, Liverpool, UK.
Aims: In the conventionally fractionated phase III FLAME prostate trial, focal boosts improved local control and biochemical disease-free survival (bDFS). We explored the toxicity and effectiveness of a moderately hypofractionated schedule with focal boosts.
Material And Methods: BIOPROP20 is a phase II single-arm non-randomised trial for intermediate- to very high-risk localised prostate cancer patients with bulky tumour volumes.
Environ Pollut
November 2024
Department of Physics, University of Girona, Girona, Spain. Electronic address:
Microplastics are known to accumulate in sediment beds of aquatic environments where they can be buried. Once buried they can remobilize due to high energetic events, entering the water column again. Here, turbulence induced by an oscillating grid device was used to investigate the remobilization of microfibers (MF) buried into the sediment bed.
View Article and Find Full Text PDFInt J Mol Sci
July 2024
Department of Earth, Environment and Life Sciences (DISTAV), University of Genoa, 16132 Genoa, Italy.
Microplastic (MP) contamination in the aquatic environment is a cause of concern worldwide since MP can be taken up by different organisms, altering different biological functions. In particular, evidence is accumulating that MP can affect the relationship between the host and its associated microbial communities (the microbiome), with potentially negative health consequences. Synthetic microfibers (MFs) represent one of the main MPs in the marine environment, which can be accumulated by filter-feeding invertebrates, such as bivalves, with consequent negative effects and transfer through the food chain.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!