Cryptococcal endocarditis has rarely been reported. Most patients with this condition are associated with risk factors, such as structural heart disease/valve replacement, immunodeficiency/immunosuppression or drug abuse. We report a case of cryptococcal endocarditis of the native valves without any risk factors. A 50-year-old Chinese man was admitted to hospital with fever for 1 month without any underlying heart disease, immunodeficiency, or drug use. He was diagnosed as having infective endocarditis and was discharged after valve replacement surgery and long-term antifungal therapy.
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http://dx.doi.org/10.1177/0300060520970763 | DOI Listing |
North Clin Istanb
April 2023
Catholic Health System, University at Buffalo, Buffalo, New York, USA.
is an exceedingly rare entity associated with high mortality and morbidity. Hereby, we present a 37-year-old patient with underlying systemic lupus erythematosus and end-stage renal disease who was diagnosed with involving native mitral valve. Her blood culture grew Cryptococcus neoformans.
View Article and Find Full Text PDFBMC Cardiovasc Disord
April 2023
Department of Internal Medicine, MedStar Georgetown University Hospital, Washington, DC, USA.
Ther Adv Infect Dis
April 2023
Division of Infection, Immunity & Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK.
Flucytosine is an antifungal agent first licensed in the 1970's. However, its clinical value has long been overlooked and its availability across the globe is limited. This review highlights the important clinical and pharmacological aspects of flucytosine.
View Article and Find Full Text PDFBMC Cardiovasc Disord
December 2022
Department of Internal Medicine, MedStar Georgetown University Hospital, 3800 Reservoir Rd NW, Washington, DC, 20007, USA.
Background: Cryptococcus neoformans is an invasive fungal infection commonly affecting immunocompromised patients as pneumonia or meningitis. More rarely, case reports describe Cryptococcus neoformans endocarditis, though nearly exclusively among patients with active immunosuppression, implanted cardiac devices or prosthetic valves.
Case Presentation: We report the case of a patient with underlying substance abuse disorder and systolic heart failure presenting with fever, altered mental status, and shower emboli subsequently found to have native tricuspid valve vegetations and blood cultures positive for cryptococcus neoformans in the absence of immunosuppression.
Infect Dis Clin Pract (Baltim Md)
November 2021
Department of Medicine, Division of Infectious Disease, Columbia University Vagelos College of Physicians & Surgeons, New York, NY.
infective endocarditis is rarely reported. In this report, we present a case of infective endocarditis secondary to in a lung-transplant recipient and review the relevant literature. A 65-year-old man was hospitalized with hypoxemic respiratory failure and underwent left-sided single lung transplantation.
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