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Advancing precision cancer immunotherapy drug development, administration, and response prediction with AI-enabled Raman spectroscopy.
Front Immunol
January 2025
Department of Surgery, Stanford School of Medicine, Stanford University Medical Center, Stanford, CA, United States.
Molecular characterization of tumors is essential to identify predictive biomarkers that inform treatment decisions and improve precision immunotherapy development and administration. However, challenges such as the heterogeneity of tumors and patient responses, limited efficacy of current biomarkers, and the predominant reliance on single-omics data, have hindered advances in accurately predicting treatment outcomes. Standard therapy generally applies a "one size fits all" approach, which not only provides ineffective or limited responses, but also an increased risk of off-target toxicities and acceleration of resistance mechanisms or adverse effects.
View Article and Find Full Text PDFRemote sighted assistance (RSA) has emerged as a conversational assistive technology for people with visual impairments (VI), where remote sighted agents provide realtime navigational assistance to users with visual impairments via video-chat-like communication. In this paper, we conducted a literature review and interviewed 12 RSA users to comprehensively understand technical and navigational challenges in RSA for both the agents and users. Technical challenges are organized into four categories: agents' difficulties in orienting and localizing the users; acquiring the users' surroundings and detecting obstacles; delivering information and understanding user-specific situations; and coping with a poor network connection.
View Article and Find Full Text PDFDesign of natural asphalt sulfamic acid (NA-NHSOH) as a scalable natural asphalt-derived heterogeneous Brønsted acid to catalyze multicomponent reactions meeting green chemistry goals.
Heliyon
January 2025
Department of Chemistry, Faculty of Basic Sciences, Ilam University, P.O. Box 69315516, Ilam, Iran.
This study highlights an innovative approach to catalysis by utilizing natural asphalt as a support material for developing carbon-based catalysts. By leveraging the principles of green chemistry, the research aims to create recyclable and environmentally friendly heterogeneous catalytic systems. This aligns with the growing demand for greener technologies and the use of biocompatible materials in chemical processes.
View Article and Find Full Text PDFMechanistic Insights into Amorphous Solid Dispersions: Bridging Theory and Practice in Drug Delivery.
Pharm Res
January 2025
Solid State Pharmaceutics Research Laboratory, Department of Pharmaceutical Sciences and Technology, Birla Institute of Technology, Mesra, Ranchi, 835215, Jharkhand, India.
Improving the bioavailability of poorly water-soluble drugs presents a significant challenge in pharmaceutical development. Amorphous solid dispersions (ASDs) have garnered substantial attention for their capability to augment the solubility and dissolution rate of poorly water-soluble drugs, thereby markedly enhancing their bioavailability. ASDs, characterized by a metastable equilibrium where the active pharmaceutical ingredient (API) is molecularly dispersed, offer enhanced absorption compared to crystalline forms.
View Article and Find Full Text PDFCorrigendum to "Mechanochemical destruction of perfluorooctane sulfonate (PFOS) using boron carbide (BC)" [ J Hazard Mater 486 (2025) 137044].
J Hazard Mater
January 2025
State Key Joint Laboratory of Environment Simulation and Pollution Control (SKLESP), Beijing, China; Key Laboratory for Emerging Organic Contaminants Control (BKLEOC), Beijing, China; Laboratory for Environmental Frontier Technologies (BLEFT), School of Environment, Tsinghua University, Beijing 100084, China. Electronic address:
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