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Genomic epidemiology of nontoxigenic from King County, Washington State, USA between July 2018 and May 2019. | LitMetric

AI Article Synopsis

  • Between July 2018 and May 2019, a study examined nontoxigenic biovar mitis bacteria from eight patients with non-respiratory infections, mostly in homeless shelters in King County, WA.
  • Whole-genome sequencing revealed that all isolates were genetically similar, falling under sequence type 445, with minimal genetic differences, indicating a related outbreak.
  • The study highlighted variations in virulence-related genes among the closely related isolates, demonstrating that genomic analysis can enhance our understanding of the epidemiology of these bacteria.

Article Abstract

Between July 2018 and May 2019, was isolated from eight patients with non-respiratory infections, seven of whom experienced homelessness and had stayed at shelters in King County, WA, USA. All isolates were microbiologically identified as nontoxigenic biovar mitis. Whole-genome sequencing confirmed that all case isolates were genetically related, associated with sequence type 445 and differing by fewer than 24 single-nucleotide polymorphisms (SNPs). Compared to publicly available genomic data, these WA isolates formed a discrete cluster with SNP variation consistent with previously reported outbreaks. Virulence-related gene content variation within the highly related WA cluster isolates was also observed. These results indicated that genome characterization can readily support epidemiology of nontoxigenic .

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8116682PMC
http://dx.doi.org/10.1099/mgen.0.000467DOI Listing

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