Background And Objective: The Kingdom of Saudi Arabia (KSA) has a high population of children with hereditary renal infections whose factors are linked to the X chromosomes. This study aims to determine the spectrum of renal pathologies in Saudi pediatrics patients as well as to link the genetic aspect to the development of renal diseases in Saudi children by using ultrasound.
Materials And Methods: The study, hence sought to analyze the outcomes of a cross-sectional retrospective study report at the Radiology department of King Fahad Medical City (KFMC) within 12 months retrogressively. Data was collected using ultrasound machines with B-mode and Doppler modes used to generate results that were later filled in forms.
Results: Demographic characteristics showed that even though the study incorporated the children between the ages of 1-14 years, renal infection was most prevalent in children between the ages 4-7 years. The study revealed that male children were at a higher risk of getting a hereditary renal infection compared to their female counterparts. Indications for renal ultrasound examination of the study samples indicated that the ectopic renal disease affected 2% of the 50 sample size, while hydronephrosis affected 26% of the sample.
Conclusion: The current study was able to successfully highlight the role of ultrasound in the detection of a wide range of renal diseases among Saudi children. Additionally, this study attempted to link the genetic aspect to the development of renal diseases in Saudi children, but the use of ultrasound alone was not very helpful in this.
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http://dx.doi.org/10.3923/pjbs.2020.1614.1620 | DOI Listing |
Pain Ther
January 2025
Department of Medicine, Nephrology Division, University of Verona, Verona, Italy.
Introduction: Pain is one of the most frequently reported symptoms in hemodialyzed (HD) patients, with prevalence rates between 33% and 82%. Risk factors for chronic pain in HD patients are older age, long-lasting dialysis history, several concomitant diseases, malnutrition, and others. However, chronic pain assessment in HD patients is rarely performed by specialists in pain medicine, with relevant consequences in terms of diagnostic and treatment accuracy.
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January 2025
Department of Urology, Guizhou Provincial People's Hospital, Guiyang, 550002, China.
Selenium, an essential trace mineral for health, has seen a rise in clinical trials over the past nearly 5 decades. Our aim here is to provide a comprehensive and concise overview of selenium clinical trials from 1976 to 2023. Overall, the evolution of selenium clinical trials over 48 years has advanced through phases of emergence, prosperity, and either stability or transition.
View Article and Find Full Text PDFApoptosis
January 2025
Department of Pharmacology, School of Basic Medical Sciences, Xi'an Jiaotong University, Xi'an, 710061, China.
Tangerine peel is a traditional Chinese herb and has been widely applied in foods and medicine for its multiple pharmacological effects. Erythropoietin receptor (EPOR), a member of the cytokine receptor family, is widely expressed in multiple tissues in especial kidney and plays protective effects in adverse physiological and pathological conditions. We hypothesized that it might be EPOR agonists existing in Tangerine peel bring such renal benefits.
View Article and Find Full Text PDFApoptosis
January 2025
Department of Endocrinology and Metabolism, The Second Affiliated Hospital of Nanchang University, Nanchang, 330006, China.
Diabetes is a chronic metabolic disease that is endemic worldwide and is characterized by persistent hyperglycemia accompanied by multiple severe complications, including cardiovascular disease, kidney dysfunction, neuropathy, and retinopathy. The pathogenesis of diabetes mellitus and its complications is multifactorial, involving various molecular and cellular pathways. In recent years, research has indicated that mechanisms of cell death play a significant role in the advancement of diabetes and its complications.
View Article and Find Full Text PDFCommun Biol
January 2025
Division of Geriatrics, Department of Medicine, SMPH, University of Wisconsin-Madison, Madison, WI, USA.
Changes in brain mitochondrial metabolism are coincident with functional decline; however, direct links between the two have not been established. Here, we show that mitochondrial targeting via the adiponectin receptor activator AdipoRon (AR) clears neurofibrillary tangles (NFTs) and rescues neuronal tauopathy-associated defects. AR reduced levels of phospho-tau and lowered NFT burden by a mechanism involving the energy-sensing kinase AMPK and the growth-sensing kinase GSK3b.
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