Long-lived memory CD8 T cells play important roles in tumor immunity. Studies over the past two decades have identified four subsets of memory CD8 T cells - central, effector, stem-like, and tissue resident memory - that either circulate through blood, lymphoid and peripheral organs, or reside in tissues where cancers develop. In this article, we will review studies from both pre-clinical mouse models and human patients to summarize the phenotype, distribution and unique features of each memory subset, and highlight specific roles of each subset in anti-tumor immunity. Moreover, we will discuss how stem-cell like and resident memory CD8 T cell subsets relate to exhausted tumor-infiltrating lymphocytes (TIL) populations. These studies reveal how memory CD8 T cell subsets together orchestrate durable immunity to cancer.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7738415 | PMC |
| http://dx.doi.org/10.1016/j.smim.2020.101435 | DOI Listing |
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