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In the past, food-based dietary guidelines (FBDGs) were derived nearly exclusively by using systematic reviews on diet-health relationships and translating dietary reference values for nutrient intake into foods. This approach neglects many other implications that dietary recommendations have on society, the economy and environment. In view of pressing challenges, such as climate change and the rising burden of diet-related diseases, the simultaneous integration of evidence-based findings from different dimensions into FBDGs is required. Consequently, mathematical methods and data processing are evolving as powerful tools in nutritional sciences. The possibilities and reasons for the derivation of FBDGs via mathematical approaches were the subject of a joint workshop hosted by the German Nutrition Society (DGE) and the Federation of European Nutrition Societies (FENS) in September 2019 in Bonn, Germany. European scientists were invited to discuss and exchange on the topics of mathematical optimisation for the development of FBDGs and different approaches to integrate various dimensions into FBDGs. We concluded that mathematical optimisation is a suitable tool to formulate FBDGs finding trade-offs between conflicting goals and taking several dimensions into account. We identified a lack of evidence for the extent to which constraints and weights for different dimensions are set and the challenge to compile diverse data that suit the demands of optimisation models. We also found that individualisation via mathematical optimisation is one perspective of FBDGs to increase consumer acceptance, but the application of mathematical optimisation for population-based and individual FBDGs requires more experience and evaluation for further improvements.
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http://dx.doi.org/10.1017/S0007114520004857 | DOI Listing |
bioRxiv
December 2024
Bioinformatics and Cellular Genomics, St Vincent's Institute of Medical Research, Fitzroy, VIC 3065, Australia.
Single-cell Assay for Transposase Accessible Chromatin with sequencing (scATAC-seq) has become a widely used method for investigating chromatin accessibility at single-cell resolution. However, the resulting data is highly sparse with most data entries being zeros. As such, currently available computational methods for scATAC-seq feature a range of transformation procedures to extract meaningful information from the sparse data.
View Article and Find Full Text PDFJ Dairy Sci
December 2024
Centre for Mathematical Modelling and Intelligent Systems for Health and Environment (MISHE), Atlantic Technological University, Sligo, Ireland.
This paper explores various approaches to modeling the bovine estrus cycle, focusing on improving estrus detection to enhance reproductive management in dairy cattle. The review examines a range of mathematical models, including hormonal models based on ordinary differential equations (ODEs) that simulate hormone dynamics, as well as follicular competition models that track the maturation of individual follicles. In addition to these, Precision Dairy Monitoring Technologies (PDMT) are discussed, which utilize real-time physiological and behavioral data to provide predictive insights into estrus.
View Article and Find Full Text PDFSci Rep
December 2024
Centre for Artificial Intelligence Research and Optimisation, Torrens University Australia, Fortitude Valley, Brisbane, QLD, 4006, Australia.
Nowadays, consumers show more interest towards eco-friendly products. To meet this demand, however, manufacturing processes often generate a lot of hazardous waste, which creates challenges for companies. To tackle these issues, this work develops an optimization model to help companies with managing production, reduce waste, and maintain green product standards.
View Article and Find Full Text PDFBioinformatics
December 2024
Laboratory of Data Discovery for Health Limited (D24H), Hong Kong SAR, China.
Summary: With the recent advancement in single-cell RNA-sequencing technologies and the increased availability of integrative tools, challenges arise in easy and fast access to large collections of cell atlas. Existing cell atlas portals rarely are open sourced and adaptable, and do not support meta-analysis at cell level. Here, we present an open source, highly optimised and scalable architecture, named Scope+, to allow quick access, meta-analysis and cell-level selection of the atlas data.
View Article and Find Full Text PDFInt Wound J
December 2024
Wound Care Centre (Centro Aziendale di Riparazione Tissutale), Castellammare di Stabia, Italy.
Negative pressure wound therapy is used often in the management of surgical incisions, chronic wounds and subacute lesions, and there are numerous publications discussing its clinical application and outcomes. However, whilst clinical use and associated literature have expanded since these systems became commercially available in the 90s, important research and discussion around the mode of action have waned, leading to a deficit in the understanding of how this important therapy influences healing. Further, much research and many publications are predominantly reflective, discussing early theorem, some of which have been proven incorrect, or at least not fully resolved leading to misunderstandings as to how the therapy works, thus potentially denying the clinician the opportunity to optimise use towards improved clinical and economic outcomes.
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