Background: A plethora of outcome measurement instruments (OMIs) are being used in port wine stain (PWS) studies. It is currently unclear how valid, responsive, and reliable these are.
Objectives: The aim of this systematic review was to appraise the content validity and other measurement properties of OMIs for PWS treatment to identify the most appropriate instruments and future research priorities.
Methods: This study was performed using the updated Consensus-Based Standards for the Selection of Health Measurement Instruments (COSMIN) methodology and adhered to PRISMA guidelines. Comprehensive searches in Medline and Embase were performed. Studies in which an OMI for PWS patients was developed or its measurement properties were evaluated were included. Two investigators independently extracted data and assessed the quality of included studies and instruments to perform qualitative synthesis of the evidence.
Results: In total, 1,034 articles were screened, and 77 full-text articles were reviewed. A total of 8 studies were included that reported on 6 physician-reported OMIs of clinical improvement and 6 parent- or patient-reported OMIs of life impact, of which 3 for health-related quality of life and 1 for perceived stigmatization. Overall, the quality of OMI development was inadequate (63%) or doubtful (37%). Each instrument has undergone a very limited evaluation in PWS patients. No content validity studies were performed. The quality of evidence for content validity was very low (78%), low (15%), or moderate (7%), with sufficient comprehensibility, mostly sufficient comprehensiveness, and mixed relevance. No studies on responsiveness, minimal important change, and cross-cultural validity were retrieved. There was moderate- to very low-quality evidence for sufficient inter-rater reliability for some clinical PWS OMIs. Internal consistency and measurement error were indeterminate in all studies.
Conclusions: There was insufficient evidence to properly guide outcome selection. Additional assessment of the measurement properties of OMIs is needed, preferentially guided by a core domain set tailored to PWS.
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http://dx.doi.org/10.1159/000511438 | DOI Listing |
Rev Bras Ortop (Sao Paulo)
December 2024
Grupo de Quadril, Departamento de Ortopedia e Traumatologia, Faculdade de Ciências Médicas da Santa Casa de Misericórdia de São Paulo (FCMSCSP), São Paulo, SP, Brasil.
To validate the Portuguese version of the evaluation instrument modified Harris Hip Score. The modified Harris Hip Score went through a validation process for the Portuguese language. We tested the measurement properties of the Brazilian Portuguese version of the modified Harris Hip Score (HHSmBr) on 100 patients (63% females and 37% males) with different hip conditions.
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December 2024
Department of Medicine, Division of Neurology, Faculty of Medicine University of Malaya Kuala Lumpur Malaysia.
Aim: This study aimed to develop and validate a Japanese version of the Public Attitudes Toward Epilepsy (PATE-J) Scale to measure attitudes towards epilepsy among the general Japanese population.
Methods: The study employed a cross-sectional design using an online survey of 537 participants from the general public in Japan, with follow-up surveys at 2 weeks and 3 months. The PATE Scale was translated following standard guidelines and validated by conducting confirmatory factor analysis (CFA) on the complete data set to assess the original two-factor structure of the PATE Scale.
Small
December 2024
SKKU Advanced Institute of Nanotechnology (SAINT), Sungkyunkwan University, Suwon, 16419, Republic of Korea.
Among 2-dimensional (2D) non-layered transition-metal chalcogenides (TMCs), cobalt sulfides are highly interesting because of their diverse structural phases and unique properties. The unique magnetic properties of TMCs have generated significant interest in their potential applications in future spintronic devices. In addition, their high conductivity, large specific surface area, and abundant active sites have attracted attention in the field of catalysis.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Geriatrics Research Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, Washington, USA.
Introduction: Genetic variation in the lysosomal and transmembrane protein 106B (TMEM106B) modifies risk for several neurodegenerative disorders, especially frontotemporal lobar degeneration (FTLD). The C-terminal (CT) domain of TMEM106B occurs as fibrillar protein deposits in the brains of dementia patients.
Methods: To determine the TMEM CT aggregation propensity and neurodegenerative potential, we generated transgenic Caenorhabditis elegans expressing the human TMEM CT fragment aggregating in FTLD cases.
Small
December 2024
Department of Chemistry, The University of British Columbia, 3247 University Way, Kelowna, BC, V1V 1V7, Canada.
Limitations in solar energy conversion by photocatalysis typically stem from poor underlying charge carrier properties. Transient Absorption (TA) reveals insights on key photocatalytic properties such as charge carrier lifetimes and trapping. However, on the microsecond timescale, these measurements use relatively large probe sizes ranging in millimetres to centimetres which averages the effect of spatial heterogeneity at smaller length scales.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!