[ARCHITECTONICS OF THE NIGHT SLEEP BASED ON ITS POLYSOMNOGRAPHIC CHARACTERISTICS IN PATIENTS WITH MULTIPLE SCLEROSIS].

Aim of our study is to establish polysomnographic characteristics of nocturnal sleep in various forms of multiple sclerosis. Fifty eight patients with different clinical course of multiple sclerosis (MS) were included into the study. Disturbances of sleep architectonics were identified: representation of deep stages of NREM sleep, as well as REM sleep were reduced. Maintenance and continuity of sleep and its architecture were affected, leading to reduced sleep efficacy. Destabilization of sleep phases can be explained by activation of desynchronizing brain systems, leading to poor organization of NREM and REM sleep. These disorders were especially pronounced in patients with progressive course of MS. Thus, abovementioned sleep disorders can have prognostic value for predicting clinical course severity in patients with MS. Management of sleep disorders can improve quality of live in people with MS.