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Climate-driven dengue fever outbreaks in Nepal: Trends, challenges, and strategies.
World J Virol
December 2024
Research Section, Nepal Health Research Council, Kathmandu 44600, Bagmati, Nepal.
Dengue fever (DF) has become a major public health concern in Nepal, with increasing outbreaks in recent years. Transmitted by Aedes mosquitoes, this climate-sensitive viral disease presents a significant challenge for healthcare providers and policymakers. Since 2004, Nepal has experienced a sharp increase in DF cases, peaking in 2022 with 54784 cases and 88 deaths.
View Article and Find Full Text PDFNovel gene mutation causing primary combined immunodeficiency disease: A case report and literature review.
Cent Eur J Immunol
September 2024
This study presents a detailed clinical case of a 10-year-old boy with a history of prolonged cough, fever, and delayed diagnosis of bronchiectasis. Review of the case revealed that the child has had recurrent bronchitis, otitis media, skin allergies, and viral warts since early childhood, indicating persistent immune system abnormalities. Imaging studies, including pulmonary and sinus CT scans, show significant bronchiectasis accompanied by infections and sinusitis.
View Article and Find Full Text PDFThe incidence and risk factors of fetuses with mirror-image dextrocardia with solitus inversus.
Cardiol Young
December 2024
Department of Ultrasound, Xi'an International Medical Center Hospital, Xi'an, Shaanxi, China.
Objective: This research seeks to ascertain the prevalence and determinants of mirror-image dextrocardia in fetuses.
Study Design: With December 2022 as the reference point, we compiled colleted data on pregnant women who carried fetuses with mirror-image dextrocardia in Xi'an, Shaanxi Province: September-October 2022, November 2022, and December 2022-January 2023. An online questionnaire was distributed to 209 pregnant across China who had contracted COVID-19.
Phase II Trial of Neoadjuvant Docetaxel/Cisplatin/5-Fluorouracil Combined with Pegteograstim for Unresectable, Locally Advanced Sinonasal Squamous Cell Carcinoma: KCSG HN18-07.
Cancer Res Treat
December 2024
Department of Oncology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
Purpose: The role of neoadjuvant chemotherapy in locally advanced sinonasal squamous cell carcinoma (SNSCC) has not been established prospectively. We conducted a phase II trial of neoadjuvant chemotherapy (NAC) with docetaxel/cisplatin/5-fluorouracil (TPF) in this population.
Materials And Methods: Eligible patients had unresectable, locally advanced SNSCC, defined as T3/4 stage or potential compromise of critical organ function on surgery.
Triple Co-infection With Salmonella typhi, Leptospira, and Campylobacter coli in a Patient From Guayaquil, Ecuador: Clinical and Diagnostic Challenges.
Cureus
November 2024
Medicine, University of Guayaquil, Guayaquil, ECU.
This case report describes the unusual presentation of a 32-year-old male from Guayaquil, Ecuador, who was diagnosed with a rare triple infection caused by , , and . The patient presented with persistent high fever, severe gastrointestinal symptoms, abdominal pain, and jaundice, following the consumption of street food in a resource-limited area. Important clinical findings included hepatosplenomegaly and elevated liver enzymes, which initially complicated the differential diagnosis.
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