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Impact of vial quality on interactions, particle formation, container closure integrity, and gas permeability for frozen drug product storage.
Eur J Pharm Sci
January 2025
Ludwig-Maximilians-Universität München, Department of Pharmacy, Pharmaceutical Technology and Biopharmaceutics, 81377 Munich, Germany. Electronic address:
The frozen storage of biopharmaceuticals brings new challenges to the primary packaging material. Due to an increasing demand and the downsides of standard type I glass vials, such as vial breakage, novel vial types for special applications of parenteral drug products have been introduced to the market in the past years. Mechanical stresses due to dimensional changes experienced during freezing and thawing could change the material properties, hence affecting the interaction with the drug product stored in the vial or functionality such as overall integrity.
View Article and Find Full Text PDFImpact of Sub-Nanoscale Surface Topography on Contact Line Profile: Insights from Coherence Scanning Interferometry.
Langmuir
January 2025
Department of Aeronautics and Astronautics, Kyushu University, Motooka 744, Nishi-Ku, Fukuoka 819-0395, Japan.
Despite the importance of the effect of subnanoscale roughness on contact line behavior, it is difficult to directly observe the local behavior of contact lines at the micro- and nanoscale, leaving significant gaps in our current understanding. In this research, we investigate contact line motions and their relationship with nanoscale surface topography using coherence scanning interferometry. Our experiments were conducted on the substrates with different wettability without changing nanoscale surface topography.
View Article and Find Full Text PDFPyrrhotite promote aerobic granular sludge formation in dye wastewater: pH, interfacial free energy, and microbial community evolution.
Bioresour Technol
December 2024
School of Civil Engineering and Architecture, Zhejiang University of Science and Technology, Hangzhou 310000, PR China; Key Laboratory of Recycling and Eco-treatment of Waste Biomass of Zhejiang Province, Hangzhou 310023, PR China.
This study introduces a technique utilizing natural pyrrhotite powder as a nucleating agent in four sequencing batch reactors (SBRs) for the treatment of dye wastewater. Through analysis of various factors including pH, pyrrhotite surface free energy, sludge zeta potential, and shifts in microbial communities, the mechanism by which pyrrhotite facilitates the formation of aerobic granular sludge (AGS) is elucidated. Over 140 days of continuous operation under neutral conditions, natural pyrrhotite rapidly cultivated AGS under neutral conditions.
View Article and Find Full Text PDFPreparation of dental resin composites with anti-bacterial adhesion against Streptococcus mutans using fluorinated and silicon containing dimethacrylates.
Dent Mater
December 2024
College of Materials Science and Engineering, South China University of Technology, Guangzhou, China. Electronic address:
Objective: The purpose of this study was to enhance the anti-bacterial adhesion effect against Streptococcus mutans (S. mutans) of fluorinated dimethacrylate (DF MA) based dental resin composites (DRCs) by using silicone dimethacrylate (SMA-MEO).
Method: The SMA-MEO was added into mixture of DFMA and tricyclo (5.
High modulus and strength polyurethane film synthesized from lignin-based polyol with various lignin contents and NCO/OH molar ratios.
Int J Biol Macromol
January 2025
State Key Laboratory of Biobased Material and Green Papermaking, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250353, China. Electronic address:
This study explored the synthesis of lignin-polyol (LP) by liquefaction of Kraft lignin in polyethylene glycol and glycerol. LP23 (23 wt% lignin) and LP41 (41 wt% lignin) were obtained with remarkable liquefaction yields of 97.43 % and 93.
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