Composite structures undergo a gradual damage evolution from initial inter-fibre cracks to extended damage up to failure. However, most composites could remain in service despite the existence of damage. Prerequisite for a service extension is a reliable and component-specific damage identification. Therefore, a vibration-based damage identification method is presented that takes into consideration the gradual damage behaviour and the resulting changes of the structural dynamic behaviour of composite rotors. These changes are transformed into a sequence of distinct states and used as an input database for three diagnostic models, based on the Kullback-Leibler divergence, the two-sample Kolmogorov-Smirnov test and a statistical hidden Markov model. To identify the present damage state based on the damage-dependent modal properties, a sequence-based diagnostic system has been developed, which estimates the similarity between the present unclassified sequence and obtained sequences of damage-dependent vibration responses. The diagnostic performance evaluation delivers promising results for the further development of the proposed diagnostic method.
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http://dx.doi.org/10.3390/e21070690 | DOI Listing |
Microbiol Spectr
December 2024
College of Ecology, Lishui University, Lishui, Zhejiang, China.
Unlabelled: and are recognized as significant opportunistic pathogens affecting aquatic animals and humans. However, their infections in amphibians are poorly documented, and their pathogenicity to the Chinese spiny frog () remains unexplored. This study investigated an outbreak of putrid-skin disease among on a farm in Lishui City, Zhejiang Province, China.
View Article and Find Full Text PDFJ Med Chem
January 2025
SANKEN, Osaka University, Mihogaoka, Ibaraki-shi, Osaka 567-0047, Japan.
Histone methylation, a crucial aspect of epigenetics, intricately involves specialized enzymes such as G9a, a histone methyltransferase (HMT) catalyzing the methylation of histone H3 lysine 9 (H3K9) and H3K27. Apart from histone modification, G9a regulates essential cellular processes such as deoxyribonucleic acid (DNA) replication, damage repair, and gene expression via modulating DNA methylation patterns. The dysregulation and overexpression of G9a are intricately linked to cancer initiation, progression, and metastasis, making it a compelling target for anticancer therapy.
View Article and Find Full Text PDFMol Omics
January 2025
Department of Biotechnology, Thapar Institute of Engineering and Technology, Patiala, Punjab, India.
The present work aimed to examine the primary mechanisms of liver damage, namely the impact of gut-derived endotoxins along the gut-liver axis and adipose-derived free fatty acids along the adipose-liver axis. These processes are known to play a significant role in the development of hepatic inflammation and steatosis. Although possible overlapping in the pathogenesis was expected, these processes have unique pathophysiological consequences.
View Article and Find Full Text PDFPlant Dis
December 2024
Northeast Agricultural University, Harbin, United States;
Vicia amoena is renowned for its high protein content and nutritional value, making it significant in animal production and traditional Chinese medicine production. In July 2023, typical anthracnose symptoms were observed on V. amoena leaves in Suihua City (125°82'E, 46°22'N), Heilongjiang Province, China, affecting approximately 40% of the plants (a total of 200 plants were surveyed).
View Article and Find Full Text PDFNature
January 2025
Laboratory of Gene Regulation and Signal Transduction, Departments of Pharmacology and Pathology, School of Medicine, University of California San Diego (UCSD), La Jolla, CA, USA.
Hepatocellular carcinoma (HCC) originates from differentiated hepatocytes undergoing compensatory proliferation in livers damaged by viruses or metabolic-dysfunction-associated steatohepatitis (MASH). While increasing HCC risk, MASH triggers p53-dependent hepatocyte senescence, which we found to parallel hypernutrition-induced DNA breaks. How this tumour-suppressive response is bypassed to license oncogenic mutagenesis and enable HCC evolution was previously unclear.
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