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Neuroprotective Metabolites from Vietnamese Marine Derived Fungi of and Genera. | LitMetric
Low molecular weight secondary metabolites of marine fungi , and sp. from Van Phong and Nha Trang Bays (Vietnam) were studied and a number of polyketides, bis-indole quinones and terpenoids were isolated. The structures of the isolated compounds were determined by 1D and 2D NMR and HR-ESI-MS techniques. Stereochemistry of some compounds was established based on ECD data. A chemical structure of asterriquinone F () was thoroughly described for the first time. Anthraquinone () was firstly obtained from a natural source. Neuroprotective influences of the isolated compounds against 6-OHDA, paraquat and rotenone toxicity were investigated. 4-Hydroxyscytalone (), 4-hydroxy-6-dehydroxyscytalone () and demethylcitreoviranol () have shown significant increasing of paraquat- and rotenone-treated Neuro-2a cell viability and anti-ROS activity.
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