Rotating MRI systems could enable novel integrated medical devices such as MRI-Linacs, MRI-xray-angiography systems, and MRI-proton therapy systems. This work aimed to investigate the feasibility of rotating actively shielded superconducting MRI magnets in the presence of environmental steel-in particular, construction steel in the floor of the installation site. Two magnets were investigated: a 1.0 T split bore magnet, and a 1.5 T closed bore magnet. Each magnet was scaled to emulate field strengths of 0.5, 1.0, and 1.5 T. Finite Element Modeling was used to simulate these magnets in the presence of a 3 × 4 m steel plate located 1250 mm or 1400 mm below the isocenter. There are two possible rotation directions: around the longitudinal (z) axis or around the transverse (x) axis. Each model was solved for rotation angles between 0 and 360° in 30° intervals around each of these axes. For each simulation, a 300 mm DSV was extracted and decomposed into spherical harmonics. For the closed-bore magnet, total induced perturbation for the zero degree rotation angle was 223, 432, and 562 μT peak-to-peak (pk-pk) for the 0.5, 1.0, and 1.5 T models respectively (steel at 1250 mm). For the split-bore magnet, the same numbers were 1477, 16747, and 1766 μT. The substantially higher perturbation for the split-bore magnet can be traced to its larger fringe field. For rotation around the z-axis, total perturbation does not change as a function of angle but is exchanged between different harmonics. For rotation around the x-axis, total perturbation is different at each rotation angle. For the closed bore magnet, maximum perturbations occurred for a 90° rotation around the transverse axis. For the split-bore magnet, the opposite was observed, with the same 90° rotation yielding total perturbation lower than the conventional position. In all cases, at least 95% of the total perturbation was composed of 1st and 2nd order harmonics. The presence of environmental steel poses a major challenge to the realization of an actively shielded rotating superconducting MRI system, requiring some novel form of shimming. Possible shimming strategies are discussed at length.
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http://dx.doi.org/10.1088/1361-6560/abd010 | DOI Listing |
Global Spine J
January 2025
Department of Orthopedics, IRCCS Galeazzi Orthopaedic Institute, Milan, Italy.
Study Design: Narrative Review.
Objective: The management of spinal tumors requires a multi-disciplinary approach including surgery, radiation, and systemic therapy. Surgical approaches typically require posterior segmental instrumentation to maintain long-term spinal stability.
J Hazard Mater
January 2025
Guangdong-Hong Kong-Macao Joint Laboratory for Contaminants Exposure and Health, Key Laboratory of Environmental Catalysis and Health Risk Control, Institute of Environmental Health and Pollution Control, Guangdong University of Technology, Guangzhou 510006, China; Guangzhou Key Laboratory of Environmental Catalysis and Pollution Control, Guangdong Basic Research Center of Excellence for Ecological Security and Green Development, School of Environmental Science and Engineering, Guangdong University of Technology, Guangzhou 510006, China. Electronic address:
Long-term occupational exposure to metals and organics have been reported to be under great health risks. However, limited data are available on the molecular mechanism between combined exposure to metals and polycyclic aromatic hydrocarbons (PAHs) and harmful health effects. In present work, non-target metabolomics study was conducted based on urine samples from nonferrous metal smelting workers (n = 207), surrounding residents (n = 180), and the control residents (n = 187) by using ultra-high-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UHPLC-QTOF-MS).
View Article and Find Full Text PDFMolecules
December 2024
Department of Biological and Chemical Sciences, The University of the West Indies, Cave Hill Campus, Wanstead P.O. Box 64, Barbados.
A computational study of X-H···Y binary hydrogen-bonded complexes was undertaken to examine the red- and blue-shifting behavior of three model X-H proton donors interacting with a series of Lewis bases: Y = NH, NCLi, NCH, NCF, CH, BF, CO, N and Ne. Two of these proton donors, FArH and FCH, have blue-shifting tendencies, while the third, FH, has red-shifting tendencies. A perturbation theory model for frequency shifts that was derived many years ago was employed to partition the predicted frequency shift into the sum of two components, one dependent on the second derivative of the interaction energy with respect to X-H displacement and the other dependent on the X-H bond length change in the binary complex.
View Article and Find Full Text PDFGenome Res
January 2025
Whitehead Institute, Cambridge, Massachusetts 02142, USA;
The Y-linked gene and its X-linked homolog survived the evolution of the human sex chromosomes from ordinary autosomes. encodes a multifunctional RNA helicase, with mutations causing developmental disorders and cancers. We find that, among X-linked genes with surviving Y homologs, is extraordinarily dosage sensitive.
View Article and Find Full Text PDFJ Proteomics
January 2025
Department of Gynecology and Obstetrics, Affiliated Jiangning Hospital of Nanjing Medical University, Nanjing 211100, Jiangsu, China. Electronic address:
COVID-19 still spreads worldwide, and repeated infections are hard to avoid. Maternal infection during pregnancy is associated with adverse maternal and neonatal outcomes. Our study used a multi-omics profiling method to explore the proteome and metabolome alteration in early embryonic development after COVID-19 infection.
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