AI Article Synopsis
- The study aimed to investigate the impact of 24 weeks of high-intensity progressive aerobic exercise on brain MRI measures in individuals with multiple sclerosis (MS).
- Eighty-six participants were randomly divided into an exercise group and a waitlist group; the exercise group showed improvements in cardiorespiratory fitness and a lower rate of relapses, but there was no significant change in brain volume.
- The findings suggest that while aerobic exercise doesn't protect against brain atrophy in MS, it could potentially help reduce relapse rates, indicating the need for further research into its therapeutic benefits.
Article Abstract
Objective: To determine whether 24 weeks of high-intensity progressive aerobic exercise (PAE) affects brain MRI measures in people with multiple sclerosis (MS).
Methods: We conducted a randomized, controlled, phase 2 trial (with a crossover follow-up) including an exercise group (supervised PAE followed by self-guided physical activity) and a waitlist group (habitual lifestyle followed by supervised PAE). Mildly to severely impaired patients with MS aged 18-65 years were randomized (1:1). The primary outcome was percentage brain volume change (PBVC) after 24 weeks, analyzed using the intention-to-treat principle.
Results: Eighty-six participants were recruited. PBVC did not change over the intervention period (mean between-group change +0.12%, 95% confidence interval [CI] -0.27 to 0.51, = 0.55). In contrast, cardiorespiratory fitness (+3.5 mL O/min/kg, 2.0 to 5.1, < 0.01) and annualized relapse rate (0.00, 0.00-0.07 vs +0.45, 0.28 to 0.61, < 0.01) improved in the exercise group.
Conclusion: These findings do not support a neuroprotective effect of PAE in terms of total brain atrophy in people with MS and it did not lead to a statistically significant difference in gray matter parenchymal fraction. PAE led to improvements in cardiorespiratory fitness and a lower relapse rate. While these exploratory findings cautiously support PAE as a potential adjunct disease-modifying treatment in MS, further investigations are warranted.
Clinicaltrialsgov Identifier: NCT02661555.
Classification Of Evidence: This study provides Level I evidence that 24 weeks of high-intensity PAE did not elicit disease-modifying effects in PBVC in people with MS. Exploratory analyses showed that PAE may reduce relapse rate.
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| http://dx.doi.org/10.1212/WNL.0000000000011241 | DOI Listing |
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