Recently, small-molecule inhibitors of general transcriptional regulators such as BET proteins and the RNA-PolII-regulating kinase CDK7 have been shown to have efficacy in multiple solid and liquid tumors. An article in this issue of identifies a nongenetic mechanism of resistance related to deficiency of folate that leads, via increased S-adenosylhomocysteine and reduced repressive histone methylation, to reactivation of a transcriptional program which promotes AML cell survival under the pressure of BET inhibition..
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| http://dx.doi.org/10.1158/2159-8290.CD-20-1333 | DOI Listing |
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The Lancet Public Health Commission on gambling.
Lancet Public Health
October 2024
Department of Global Health and Population, Harvard TH Chan School of Public Health, Harvard University, Cambridge, MA, USA.
Protocol for a pilot cluster randomised controlled trial of PRoGRAM-A (preventing gambling-related harm in adolescents): a secondary school-based social network intervention.
Pilot Feasibility Stud
August 2024
Centre for Trials Research, School of Medicine, Cardiff University, Cardiff, UK.
Background: In the UK, recent evidence of young people and gambling indicates a higher prevalence of gambling in comparison to other addictive behaviours. Engaging in gambling-related behaviour at a young age is associated with short and long-term consequences, including financial, emotional, academic, interpersonal, and physical and mental health detriments; otherwise known as gambling-related harms (GRH). Given the unique vulnerability of this younger group, early interventions aimed at delaying or preventing gambling are critical.
View Article and Find Full Text PDFThe prevalence of gambling and problematic gambling: a systematic review and meta-analysis.
Lancet Public Health
August 2024
National Drug and Alcohol Research Centre, University of New South Wales, Sydney, NSW, Australia.
Background: Gambling behaviours have become of increased public health interest, but data on prevalence remain scarce. In this study, we aimed to estimate for adults and adolescents the prevalence of any gambling activity, the prevalence of engaging in specific gambling activities, the prevalence of any risk gambling and problematic gambling, and the prevalence of any risk and problematic gambling by gambling activity.
Methods: We performed a systematic review and meta-analysis.
Exploring the Differences in Positive Play among Various Sports Wagering Behaviors.
J Gambl Stud
April 2024
Center on Alcohol, Substance Use, And Addictions (CASAA), University of New Mexico, 2650 Yale BLVD SE, Albuquerque, NM, USA.
Recent technological advances and legislative changes have led to an increase of sports wagering across the United States, raising concerns about possible increases in problem gambling behaviors. This, in turn, points to an increased need to understand responsible gambling and how it relates to sports gambling behaviors. The present work utilizes the Positive Play Scale (PPS), a recent scale designed to measure the increasingly popular responsible gambling concept of Positive Play, to assess how various aspects of sports gambling relate to responsible gambling.
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