AI Article Synopsis
- Irisin, a hormone linked to muscle activity, was studied in hemodialysis patients to assess its levels and effects on health outcomes, particularly mortality.
- Findings indicated that lower muscle mass and higher inflammation (measured by IL-6) were related to higher irisin levels, suggesting that body composition and inflammatory status affect hormone concentration.
- Higher serum irisin levels at baseline and increased levels over a year correlated with an increased risk of death, pointing to a potential connection between irisin, inflammation, and mortality.
Article Abstract
Objective: Irisin is a hormone released by muscle in response to exercise that acts on white adipose cells to stimulate browning of adipose tissue. We aimed to examine irisin correlates and consequences of irisin in patients receiving hemodialysis.
Design And Methods: A prospective cohort study was conducted using data from 749 prevalent patients receiving hemodialysis. Multivariable linear regression and multivariable generalized estimating equations were used to determine correlates of baseline and change in serum irisin concentration. Proportional hazards (Cox) regression was used to assess the association between serum irisin concentration and time to death.
Results: Age and body mass index were inversely associated with baseline and change in serum irisin concentration. Lower muscle mass as estimated by serum creatinine concentration was associated with lower irisin concentration (-1.38% per mg/dL (95% confidence interval [CI]: -2.45, -0.21) and with a 0.72% decrease in irisin concentration (95% CI: -1.48, -0.04) from baseline to 12 months. Each 50% higher serum interleukin-6 (IL-6) concentration was associated with 1.52% higher serum irisin concentration (95% CI: 0.38, 2.66) at baseline and an increase of 1.04% in irisin concentration over 1 year (95% CI: 0.47, 1.61). Irisin concentration at baseline was associated with higher hazard of death (hazards ratio: 1.45, 95% CI: 1.05 2.00); an increase in irisin concentration over 1 year was associated with a higher hazard of death (hazards ratio: 1.34, 95% CI: 1.01, 1.79). In formal mediation analysis, serum IL-6 was a mediator in the association between serum irisin and mortality.
Conclusions: Lower serum creatinine (reflecting lower muscle mass) and higher serum IL-6 were associated with higher serum irisin concentrations. Higher serum irisin concentrations were associated with higher mortality, which may be mediated by inflammation.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8160018 | PMC |
| http://dx.doi.org/10.1053/j.jrn.2020.05.005 | DOI Listing |
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