AI Article Synopsis
- Stereotactic body radiotherapy (SBRT) provides high doses of radiation to vertebral metastases while protecting the spinal cord, and a new method using anti-CEA PET imaging enhances target volume determination for patients with metastatic breast or thyroid cancer.
- In a study involving eight patients, iPET was performed alongside MRI and PET-CT scans, identifying more vertebral lesions than traditional methods and affecting clinical target volume (CTV) delineation in 70% of cases.
- The findings suggest that iPET improves mapping of affected vertebral segments, offering valuable additional information for planning effective SBRT treatments in cases of metastatic vertebral disease.
Article Abstract
(1) Background: Stereotactic body radiotherapy (SBRT) for vertebral metastases (VM) allows the delivery of high radiation doses to tumors while sparing the spinal cord. We report a new approach to clinical target volume (CTV) delineation based on anti-carcinoembryonic antigen (CEA) positron emission tomography (pretargeted immuno-PET; "iPET") in patients with metastatic breast cancer (BC) or medullary thyroid cancer (MTC). (2) Methods: All patients underwent iPET, spine magnetic resonance imaging (MRI), and positron emission tomography-computed tomography (PET-CT) using F-deoxyglucose (FDG) for BC or F-dihydroxy-phenylalanine (F-DOPA) for MTC. Vertebrae locations and vertebral segments of lesions were recorded and the impact on CTV delineation was evaluated. (3) Results: Forty-six VM eligible for SBRT following iPET were evaluated in eight patients (five BC, three MTC). Eighty-one vertebral segments were detected using MRI, 26 with FDG or F-DOPA PET/CT, and 70 using iPET. iPET was able to detect more lesions than MRI for vertebral bodies (44 vs. 34). iPET-based delineation modified MRI-based CTV in 70% (32/46) of cases. (4) Conclusion: iPET allows a precise mapping of affected VM segments, and adds complementary information to MRI in the definition of candidate volumes for VM SBRT. iPET may facilitate determining target volumes for treatment with stereotactic body radiotherapy in metastatic vertebral disease.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7760481 | PMC |
| http://dx.doi.org/10.3390/biomedicines8120548 | DOI Listing |
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