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Evaluation of cardiac function using echocardiography in childhood-onset systemic lupus erythematosus patients treated with hydroxychloroquine.
Expert Rev Cardiovasc Ther
December 2024
Division of Pediatric Rheumatology, Department of Pediatrics, Hacettepe University Faculty of Medicine, Ankara, Turkey.
Background: This study aimed to evaluate the effects of hydroxychloroquine on cardiac functions and left ventricular mass in patients with childhood-onset systemic lupus erythematosus (cSLE).
Research Design And Methods: Fifty patients with cSLE undergoing treatment with hydroxychloroquine underwent echocardiographic evaluation. All patients exhibited negative disease activity markers and were clinically in remission.
Efficacy of combining aspirin with hydroxychloroquine in pregnancies at high risk for pre-eclampsia: a prospective, multicentre, open-label, single-arm clinical trial, investigator-initiated study (HUGS study).
BMJ Open
December 2024
Department of Obstetrics and Gynecology, Samsung Medical Center, Seoul, Korea (the Republic of).
Introduction: The use of hydroxychloroquine (HCQ) during pregnancies complicated by systemic lupus erythematosus or refractory antiphospholipid antibody syndrome has demonstrated a significant ability to prevent pre-eclampsia (PE). As such, the potential for the administration of HCQ to prevent PE in other high-risk pregnancies is an important clinical research agenda among maternal and fetal medicine specialists. Mechanistically, the anti-inflammatory and immunomodulatory effects of HCQ can offer vascular protection and inhibit the placental dysfunction-associated thrombotic changes underlying the pathophysiology of PE, fetal growth restriction (FGR) and fetal death in utero (FDIU).
View Article and Find Full Text PDFPorphyria cutanea tarda: a unique iron-related disorder.
Hematology Am Soc Hematol Educ Program
December 2024
Harvard Medical School, Boston, MA.
The porphyrias are a group of disorders of heme biosynthesis, each characterized by an enzymatic defect in the heme biosynthetic pathway. Porphyria cutanea tarda (PCT) arises due to the inhibition of uroporphyrinogen decarboxylase (UROD) in the presence of hepatic iron and oxidative stress. Most patients with PCT have evidence of siderosis on liver biopsy, and the disease resolves with iron depletion.
View Article and Find Full Text PDFEvaluation and prediction of relapse risk in stable systemic lupus erythematosus patients after glucocorticoid withdrawal (PRESS): an open-label, multicentre, non-inferiority, randomised controlled study in China.
Ann Rheum Dis
November 2024
Department of Rheumatology, Beijing Hospital, National Centre of Gerontology, Institute of Geriatric Medicine, Clinical Immunology Centre, Chinese Academy of Medical Sciences, Beijing, China
Article Synopsis
- The study aimed to analyze the relapse rates in systemic lupus erythematosus (SLE) patients after stopping glucocorticoids (GC) with or without hydroxychloroquine (HCQ) maintenance therapy.
- Conducted over 33 weeks, the trial divided 333 patients into three groups: one that stopped both drugs, one that only stopped GC while continuing HCQ, and one that continued both treatments.
- Results showed higher relapse rates in the drug-free group (26.1%) compared to both HCQ (11.2%) and dual maintenance (4.7%) groups, indicating that continuing HCQ could help prevent relapses after stopping GC.
Analysis of Pregnancy Outcomes in Patients Exhibiting Recurrent Miscarriage With Concurrent Low-Titer Antiphospholipid Antibodies.
Am J Reprod Immunol
November 2024
Department of Rheumatology and Immunology, The Third Affiliated Hospital, Guangzhou Medical University, Guangzhou, China.
Article Synopsis
- Antiphospholipid syndrome (APS) is an autoimmune disorder affecting blood clotting and pregnancy outcomes, defined by the presence of antiphospholipid antibodies (aPLs), with recent criteria requiring higher antibody levels for diagnosis.
- This study analyzed the pregnancy outcomes in 252 pregnancies of recurrent miscarriage (RM) patients, focusing on the effects of treatment in those with low-titer aPLs, splitting them into treated and untreated groups.
- Results showed varied positivity rates for different aPL types among treated and untreated patients, suggesting treatment may influence pregnancy success in women with low-titer aPLs, although outcomes were still being assessed.
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