and as significant hub genes for vein graft restenosis.

Background: Vein graft restenosis (VGR), which appears to be caused by dyslipidemia following vascular transplantation, seriously affects the prognosis and long-term quality of life of patients.

Methods: This study analyzed the genetic data of restenosis (VGR group) and non-stenosis (control group) vessels from patients with coronary heart disease post-vascular transplantation and identified hub genes that might be responsible for its occurrence. GSE110398 was downloaded from the Gene Expression Omnibus database. A repeatability test for the GSE110398 dataset was performed using R language. This included the identification of differentially expressed genes (DEGs), enrichment analysis via Metascape software, pathway enrichment analysis, and construction of a protein-protein interaction network and a hub gene network.

Results: Twenty-four DEGs were identified between VGR and control groups. The four most important hub genes (, , , and ) were identified, and Pearson's correlation coefficient showed that and were significantly correlated with VGR. could also sensitively predict VGR (0.9 < area under the curve ≤1).

Conclusion: and were differentially expressed in vessels with and without stenosis after vascular transplantation, suggesting that these genes or their encoded proteins may be involved in the occurrence of VGR.