AI Article Synopsis
Article Abstract
Purpose: The objective of this study was to develop silibinin-loaded hydrogel for skin protection against UVB damage.
Method: Physical grafting was used to prepare hydrogel based on chitosan-fucoidan. Then, hydrogel properties, such as swelling, drug release rates, morphology, and structure, were evaluated to determine the optimum hydrogel for studies. In experiments, the silibinin permeability parameters were investigated through normal and UV-irradiated skin, anti-inflammatory property, and antioxidant effects after application of optimum hydrogel.
Results: The silibinin completely dispersed in the hydrogel, and FT-IR results showed that silibinin reacted with the chitosan and fucoidan and demonstrated a slow release pattern. The 50% and less than 70% of the drug-loaded on hydrogel were passed through normal and irradiated skin after 48 h, respectively. studies showed the effectiveness of optimized hydrogel in preventing the production of oxidative species and HO after UVB radiation. Histological studies have shown that silibinin-loaded optimized hydrogel can prevent the hyperkeratosis, acanthosis, and infiltration of neutrophils into the dermis by UVB.
Conclusion: Optimized hydrogel effectively reduced the inflammation mediators interleukin-22 and TNF-α, which signify tissue destruction. Therefore, silibinin-loaded hydrogel can be introduced as an effective sun-protective product.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1080/10837450.2020.1856871 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Optimizing voriconazole-loaded thermoresponsive hydrogel: tools and studies.
Drug Dev Ind Pharm
January 2025
Department of Pharmaceutical Sciences and Drug Research, Punjabi University, Patiala, India.
Objective: The present study aims to develop and evaluate the voriconazole-loaded thermoresponsive hydrogel using tools.
Methods: Poloxamer 407 and PEG 400 were selected as the components from studies for thermoresponsive hydrogel of voriconazole. The cohesive energy density (CED) and solubility parameters (SP) were calculated using Biovia Material Studio 2022 software to predict the polymer-polymer miscibility and drug-polymer miscibility.
Functionalized amino acid-based injectable hydrogels for sustained drug delivery.
Soft Matter
January 2025
Department of Chemistry and Chemical Biology, Indian Institute of Technology (ISM), Dhanbad-826004, India.
Drug delivery vehicles optimize therapeutic outcomes by enhancing drug efficacy, minimizing side effects, and providing controlled release. Injectable hydrogels supersede conventional ones in the field of drug delivery owing to their less invasive administration and improved targeting. However, they face challenges such as low biodegradability and biocompatibility, potentially compromising their effectiveness.
View Article and Find Full Text PDFAlopecia Management Potential of Rosemary-Based Nanoemulgel Loaded with Metformin: Approach Combining Active Essential Oil and Repurposed Drug.
Int J Nanomedicine
January 2025
Department of Pharmaceutical Sciences, School of Pharmacy, Lebanese American University, Byblos, Lebanon.
Introduction: Androgenetic alopecia (AGA) is a multifactorial and age-related dermatological disease that affects both males and females, usually at older ages. Traditional hair repair drugs exemplified by minoxidil have limitations such as skin irritation and hypertrichosis. Thus, attention has been shifted to the use of repurposing drugs.
View Article and Find Full Text PDFReview on application of silk fibroin hydrogels in the management of wound healing.
Int J Biol Macromol
January 2025
State Key Laboratory of Resource Insects, Southwest University, Chongqing 400716, China. Electronic address:
Wounds are regarded as disruptions in the integrity of human skin tissues, and the process of wound healing is often characterized as protracted and complex, primarily due to the potential infection or inflammation caused by microorganisms. The quest for innovative solutions that accelerate wound healing while prioritizing patient safety and comfort has emerged as a focal point. Within this pursuit, silkworm silk fibroin-a natural polymer extracted from silk cocoons-exhibits a distinctive combination of properties including biocompatibility, biodegradability, superior mechanical strength, water absorption, and low immunogenicity, which align closely with the demands of contemporary wound care.
View Article and Find Full Text PDFInnovating chitosan-based bioinks for dermal wound healing: Current progress and future prospects.
Int J Biol Macromol
January 2025
Cellular and Molecular Research Center, Iran University of Medical Sciences, Tehran, Iran; Department of Medical Biotechnology, Faculty of Allied Medicine, Iran University of Medical Sciences, Tehran, Iran; Department of Tissue Engineering and Regenerative Medicine, Faculty of Advanced Technologies in Medicine, Iran University of Medical Sciences, Tehran, Iran; NanoBiotechnology & Regenerative Medicine Innovation Group, Noavarn Salamat ZHINO (PHC), Tehran, Iran. Electronic address:
The field of three-dimensional (3D) bio/printing, known as additive manufacturing (AM), heavily relies on bioinks possessing suitable mechanical properties and compatibility with living cells. Among the array of potential hydrogel precursor materials, chitosan (CS) has garnered significant attention due to its remarkable physicochemical and biological attributes. These attributes include biodegradability, nontoxicity, antimicrobial properties, wound healing promotion, and immune system activation, making CS a highly appealing hydrogel-based bioink candidate.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!