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Serotype 3 Streptococcus pneumoniae Escapes the Immune Responses Induced by PCV13 in Mice With High Susceptibility to Infection.
Immun Inflamm Dis
December 2024
Bacteriology Laboratory, Instituto Butantan, São Paulo, Brazil.
Background: Streptococcus pneumoniae (pneumococcus) is a common cause of respiratory and invasive infections in humans. PCV13, a pneumococcal conjugate vaccine used globally, is highly effective against diseases caused by pneumococcal serotypes included in its formulation. However, one of them, the serotype 3 (ST3) is still being relatively commonly isolated from patients, suggesting an escape from vaccine-induced immunity.
View Article and Find Full Text PDFAssociation of Hematological and Biochemical Parameters and HLA-DRB1 Alleles With Anti-cyclic Citrullinated Peptide Autoantibodies in Sudanese Rheumatic Patients.
Cureus
April 2024
Department of Basic Medical Sciences, Faculty of Applied Medicla Sciences, Al-Baha University, Al-Baha, SAU.
Introduction Anti-citrullinated protein/peptide antibodies (ACPA) are crucial for the diagnosis and prognosis of rheumatoid arthritis (RA) and are associated with class II HLA-DRB1 alleles. The study's goal was to determine how DRB1 alleles and hematological and biochemical parameters affect ACPA production in RA patients from Sudan. Methods The study analyzed the hematological and biochemical parameters and the frequency of HLA-DRB1 alleles in 120 RA patients and 100 controls.
View Article and Find Full Text PDFSeminoperitoneum in a Dog with a History of a Vasectomy: Case Report.
J Am Anim Hosp Assoc
May 2024
Department of Pathobiological Sciences (K.F.), University of Wisconsin-Madison, Madison, WI.
An 8 yr old male German shorthaired pointer was presented on July 4, 2022, for acute abdominal and testicular pain. The dog was vasectomized at an unknown age under the care of his previous owners. The dog had an enlarged, painful left testis, scrotal edema, and an enlarged, nonpainful prostate.
View Article and Find Full Text PDFAnalysis of maternal Fc gamma receptor IIIb isoantibodies using immunomagnetic negative selected neutrophils.
Vox Sang
July 2024
Department of Clinical and Experimental Oncology, Universidade Federal de São Paulo, UNIFESP, São Paulo, Brazil.
Article Synopsis
- The study focuses on two cases of maternal anti-Fc-gamma-receptor-IIIb isoimmunization that did not show neonatal alloimmune neutropenia (NAIN) symptoms, highlighting the necessity of neutrophil isolation for diagnosing autoimmune conditions.
- Researchers compared two neutrophil isolation methods: immunomagnetic negative selection (IMNS) and traditional dextran/Ficoll, finding IMNS significantly produced more neutrophils in less time, despite being costlier.
- The findings underscore the importance of recognizing asymptomatic cases that could lead to severe neutropenia and validate IMNS as a superior method for neutrophil isolation in serological assays.
Leukotriene B4-induced neutrophil extracellular traps impede the clearance of Pneumocystis.
Eur J Immunol
May 2024
Beijing Key Laboratory of Emerging Infectious Diseases, Institute of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, China.
Pneumocystis pneumonia (PCP) is a fungal pulmonary disease with high mortality in immunocompromised patients. Neutrophils are essential in defending against fungal infections; however, their role in PCP is controversial. Here we aim to investigate the effects of neutrophil extracellular traps (NETs) on Pneumocystis clearance and lung injury using a mouse model of PCP.
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